血清Neurtin与TGF-β1对脊柱骨折患者神经功能恢复的预测作用  

Predictive effect of serum Neurtin and TGF-β1 on neurological recovery in patients with spinal fracture

作　　者：丁帅[1] 张广泉[1] 高延征[1] 王红强[1] 侯志强 邵富强 DING Shuai;ZHANG Guang-quan;GAO Yan-zheng;WANG Hong-qiang;HOU Zhi-qiang;SHAO Fu-qiang(Spinal and Spinal Cord Surgery Department,Henan Provincial Peoples Hospital,Zhengzhou 450003,China)

机构地区：[1]河南省人民医院脊柱脊髓外科,郑州450003

出　　处：《医药论坛杂志》2024年第24期2594-2598,2604,共6页Journal of Medical Forum

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20230041)。

摘　　要：目的 探讨血清Neurtin、TGF-β1对脊柱骨折患者神经功能恢复的预测作用。方法选择2018年6月—2023年12月在河南省人民医院接受治疗的脊柱骨折患者,根据其神经功能恢复程度分为预后良好组41例和预后不良组29例。收集两组患者一般资料,检测血清Neurtin、TGF-β1水平,采用logistic回归分析影响脊柱骨折患者神经功能恢复的危险因素,ROC曲线评估血清Neurtin、TGF-β1对脊柱骨折患者神经功能恢复的预测价值。结果经过对比,两组患者的年龄、性别、BMI、受伤至入院时间、受伤原因、脊髓损伤节段无统计学差异(P>0.05);预后不良组的血清Neurtin、TGF-β1水平均明显高于预后良好组,有统计学差异(P<0.05);logistic结果表明血清Neurtin、TGF-β1水平偏高是影响脊柱骨折患者神经功能恢复的独立危险因素(P<0.05);ROC分析结果表明,Neurtin、TGF-β1单独诊断脊柱骨折患者神经功能恢复的AUC为0.731、0.807,灵敏度分别为62.96%、75.93%,特异度均为77.78%,联合诊断AUC为0.892,灵敏度和特异度分别为88.89%、79.63%。结论血清Neurtin、TGF-β1指标可以作为对脊柱骨折患者神经功能恢复程度的预测的指标,联合诊断的价值较高。Objective To explore the predictive effect of serum Neurtin and TGF-β1 on neurological function recovery of spinal fracture patients.Methods Patients with spinal fracture who received treatment in our hospital from June 2018 to December 2023 were selected and divided into 41 cases in the group with good prognosis and 29 cases in the group with bad prognosis according to the degree of recovery of their neurological function.The general data of patients in the two groups were collected,serum Neurtin and TGF-β1 levels were detected,logistic regression was used to analyze the risk factors affecting the recovery of neurological function in patients with spinal fracture,and ROC curves were used to assess the predictive value of serum Neurtin and TGF-β1 on the recovery of neurological function in patients with spinal fracture.Results After comparison,there was no statistically significant difference in age,gender,BMI,time from injury to admission,cause of injury,and spinal cord injury segment between the two groups(P>0.05);serum Neurtin and TGF-β1 levels in the poor prognosis group were significantly higher than those in the good prognosis group,with statistically significant differences(P<0.05);logistic results showed that serum Neurtin,TGF-β1 levels were high as an independent risk factor affecting neurological recovery in patients with spinal fracture(P<0.05);ROC analysis showed that the AUC of Neurtin and TGF-β1 alone for diagnosing neurological recovery in patients with spinal fracture was 0.731 and 0.807,with a sensitivity of 62.96%and 75.93%,respectively,and a specificity of 77.78%for both.The combined diagnostic AUC was 0.892,with a sensitivity and specificity of 88.89%and 79.63%,respectively.Conclusion Serum Neurtin and TGF-β1 indexes can be used as predictive indicators of the degree of neurological recovery in patients with spinal fracture,and the value of combined diagnosis is high.

关 键 词：脊柱骨折 血清水平 神经功能 

分 类 号：R683[医药卫生—骨科学]