金双歧联合rhGH治疗特发性矮小症儿童的疗效及对骨代谢的影响  

Therapeutic effect of live combined bifidobacterium and Lactobacillus Tablets combined with rhGH on ISS children and its influence on bone metabolism

作　　者：张彦芳[1] 张少华[1] 廖立夏 王贝贝[1] 赵庆 王雪丽 ZHANG Yan-fang;ZHANG Shao-hua;LIAO Li-xia;WANG Bei-bei;ZHAO Qing;WANG Xue-li(Department of Pediatrics,the First People's Hospital of Nanyang City,Henan University Affiliated Hospital,Nanyang,Henan 473000,China)

机构地区：[1]河南大学附属南阳市第一人民医院儿科,河南南阳473000

出　　处：《医药论坛杂志》2024年第24期2645-2649,共5页Journal of Medical Forum

基　　金：南阳市科技攻关计划项目(KJGG193)。

摘　　要：目的 探究金双歧联合重组人生长激素(recombinant human growth hormone,rhGH)治疗特发性矮小症(Idiopathic short stature,ISS)儿童的疗效及对骨代谢的影响。方法选择2020年5月—2023年5月入住河南大学附属南阳市第一人民医院儿科的94例青春期前ISS儿童为对象实施前瞻性研究,按照随机数字表法分为研究组47例、对照组47例。对照组接受rhGH治疗,研究组在对照组基础上联合金双歧治疗,比较两组生长发育指标、骨代谢指标、血清IGF-1、IGFBP-3水平、不良反应的差异。结果与治疗前相比,治疗6个月后两组Ht、BA、Wt、GV、HtSDS均升高(P<0.05);且研究组Ht、BA、Wt、GV、HtSDS均优于对照组(P<0.05)。重复测量显示,两组PINP、BAP的时点效应/组间效应/交互效应、β-CTX的时点效应/组间效应比较差异存在统计学意义(P<0.05),与治疗前比较,治疗3个月后、治疗6个月后两组PINP、BAP均升高,β-CTX均降低(P<0.05),但治疗3个月后、治疗6个月后,与对照组相比,研究组PINP、BAP、β-CTX均更优(P<0.05)。重复测量显示,两组IGF-1、IGFBP-3的时点效应/组间效应/交互效应比较差异存在统计学意义(P<0.05),与治疗前比较,治疗3个月后、治疗6个月后两组IGF-1、IGFBP-3均升高(P<0.05),但治疗3个月后、治疗6个月后,与对照组相比,研究组IGF-1、IGFBP-3均更优(P<0.05)。两组不良反应发生状况相较无差异(P>0.05)。结论金双歧联合rhGH治疗ISS儿童疗效确切,可有效促进生长发育,改善骨代谢指标,且安全性较好。Objective To explore the curative effect of live combined bifidobacterium and lactobacillus tablets combined with recombinant human growth hormone(rhGH)on children with idiopathic short stature(ISS)and its influence on bone metabolism.Methods Totally 94 pre-adolescent ISS children admitted to our department from May 2021-May 2023 were selected for prospective study,and were randomly divided into study group and control group,with 47 cases in each group.The control group was treated with live combined bifidobacterium and lactobacillus tablets,and the study group was treated with alloy bifidus on the basis of the control group.The differences of growth and development indexes,bone metabolism indexes,serum IGF-1,IGFBP-3 levels and adverse reactions between the two groups were compared.Results Compared with the pre-treatment period,Ht,BA,Wt,GV,and HtSDS were elevated in both groups after 6 months of treatment(P<0.05);and Ht,BA,Wt,GV,and HtSDS in the study group were better than those in the control group(P<0.05).Repeated measurements showed that the difference between the time-point effect/intergroup effect/interaction effect of PINP and BAP,and the time-point effect/intergroup effect ofβ-CTX was statistically significant in the two groups(P<0.05),and compared with the pre-treatment period,the PINP and BAP were elevated andβ-CTX was decreased in the two groups after 3 months of treatment and after 6 months of treatment(P<0.05),but the PINP and BAP were elevated andβ-CTX was decreased in the two groups after 3 months of treatment,after 6 months of treatment,and after 6 months of treatment,but after 3 months of treatment and months later,PINP,BAP,andβ-CTX were superior in the study group compared with the control group(P<0.05).Repeated measurements showed that the difference in point-in-time effect/between-group effect/interaction effect comparison of IGF-1 and IGFBP-3 between the two groups was statistically significant(P<0.05),and IGF-1 and IGFBP-3 were elevated in the study group compared with the pre-treatment

关 键 词：特发性矮身材 儿童 金双歧 重组人生长激素 疗效 骨代谢 

分 类 号：R272[医药卫生—中医儿科学]