银杏叶提取物联合羟苯磺酸钙治疗非增殖期糖尿病视网膜病变疗效观察  

Effect of Ginkgo biloba extract combined with calcium dobesilate in treatment patients with non-proliferative diabetic retinopathy

作　　者：焦建慈 王敬博 陈霞 陈素英 JIAO Jian-ci;WANG Jing-bo;CHEN Xia;CHEN Su-ying(Department of Ophthalmology,the Third People's Hospital of Henan Province,Zhengzhou 450006,China)

机构地区：[1]河南省直第三人民医院眼科,郑州450006

出　　处：《医药论坛杂志》2024年第24期2650-2654,共5页Journal of Medical Forum

摘　　要：目的 探讨银杏叶提取物联合羟苯磺酸钙治疗非增殖期糖尿病视网膜病变(non-proliferative diabetic retinopathy, NPDR)的临床疗效,及其对患者视力、血流动力学、血管内皮功能的影响。方法 回顾性分析河南省直第三人民医院2022年1月—2023年12月收治的178例NPDR患者的临床资料,根据临床治疗方案不同分为西药组(n=90)和中西药联合组(n=88)。西药组采取羟苯磺酸钙治疗,中西药联合组采取银杏叶提取物联合羟苯磺酸钙治疗。治疗3个月后,比较两组临床疗效、视力、眼压改善情况、治疗前后血流动力学指标[视网膜中央动脉的收缩期峰值流速(PSV)、阻力指数(RI)及中央静脉的回流速度(CRV)、舒张末期的流速(EDV)]、血管内皮功能指标[血管内皮生长因子(VEGF)、细胞间黏附分子-1(ICAM-1)、血管生成素-2(Ang-2)]、不良反应情况。结果 治疗3个月后,中西药联合组临床总有效率为97.73%,高于西药组的88.89%(P<0.05);中西药联合组视力升高幅度及眼压降低幅度均大于西药组(P<0.05);中西药联合组PSV、EDV高于西药组,CRV、RI、血清VEGF、ICAM-1、Ang-2水平低于西药组(P<0.05);治疗期间,中西药联合组不良反应总发生率为14.77%,略高于西药组的12.22%,但组间比较无统计学差异(P>0.05)。结论 银杏叶提取物联合羟苯磺酸钙治疗NPDR患者可有效调节NPDR患者的血流动力学,改善血管内皮功能,降低眼压,改善视力,进一步提升临床疗效,且具有较高的用药安全性。Objective To investigate the clinical efficacy of Ginkgo biloba extract combined with calcium dobesilate in the treatment of non-proliferative diabetic retinopathy(NPDR) and its effects on visual acuity, hemodynamics and vascular endothelial function.Methods Clinical data of 178 NPDR patients admitted to our hospital from January 2022 to December 2023 were retrospectively selected, and divided into western medicine group(n=90) and Chinese and western medicine combined group(n=88) according to different clinical treatment plans. The western medicine group was treated with calcium dobesilate, and the Chinese and western medicine combined group was treated with ginkgo biloba extract combined with calcium dobesilate. After 3 months of treatment, the clinical efficacy, visual acuity, intraocular pressure, hemodynamic indexes [peak systolicvelocity(PSV), resistance index(RI), central venous return velocity(CRV), end diastolic velocity(EDV)], vascular endothelial function indicators [vascular endothelial growth factor(VEGF), intercellular adhesion molecules 1(ICAM-1), angiopoietin-2(Ang-2)] and adverse reactions were compared between the two groups.Results After 3 months of treatment, the total effective rate of Chinese and western medicine combined group was 97.44%, which was higher than that of the western medicine group(88.89%)(P<0.05). The increase of visual acuity and the decrease of intraocular pressure in the Chinese and western medicine combined group were greater than those in the western medicine group(P<0.05). PSV and EDV in Chinese and western medicine combined group were higher than those in western medicine group, and the CRV, RI, serum VEGF, ICAM-1 and Ang-2 levels were lower than those in Western medicine group(P<0.05). During the treatment period, the total incidence of adverse reactions in the Chinese and western medicine combined group was 14.77%, which was slightly higher than that in the western group(12.22%), bu with no significant difference(P>0.05).Conclusion Ginkgo biloba extract combined with c

关 键 词：糖尿病视网膜病变 非增殖期 银杏叶提取物 羟苯磺酸钙 视力 血流动力学 血管内皮功能 

分 类 号：R587.2[医药卫生—内分泌]