Two-dimensional Health State Map to define metabolic health using separated static and dynamic homeostasis features:a proof-of-concept study  

作　　者：Yanpu Wu Xinyan Zhang Liang Sun Qingqing Wu Xiaoping Liu Yueyi Deng Zhenzhen Lu Zhongxia Li Chaoming Deng Ruikun He Luyun Zhang Rong Zeng Xuguang Zhang Luonan Chen Xu Lin 

机构地区：[1]Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences,Shanghai 200031,China [2]BYHEALTH Institute of Nutrition&Health,Guangzhou 510799,China [3]Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China [4]Key Laboratory of Systems Biology,Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China [5]Department of Nutrition and Food Hygiene,School of Public Health,Institute of Nutrition,Fudan University,Shanghai 200032,China [6]Department of Nephrology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200030,China [7]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China

出　　处：《National Science Review》2025年第1期48-62,共15页国家科学评论(英文版)

基　　金：supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB38000000);the BYHEALTH Nutrition and Health Research Foundation(TY0191114);the Shanghai Municipal Science and Technology Major Project(2017SHZDZX01);the Ministry of Science and Technology of China(2023YFC2506702 and 2023YFC2506704).

摘　　要：Defining metabolic health is critical for the earlier reversing of metabolic dysfunction and disease,and fasting-based diagnosis may not adequately assess an individual’s metabolic adaptivity under stress.We constructed a novel Health State Map(HSM)comprising a Health Phenotype Score(HPS)with fasting features alone and a Homeostatic Resilience Score(HRS)with five time-point features only(t=30,60,90,180,240 min)following a standardized mixed macronutrient tolerance test(MMTT).Among 111 Chinese adults,when the same set of fasting and post-MMTT data as for the HSM was used,the mixed-score was highly correlated with the HPS.The HRS was significantly associated with metabolic syndrome prevalence,independently of the HPS(OR[95%CI]:0.41[0.18,0.92])and the mixed-score(0.34[0.15,0.69]).Moreover,the HRS could discriminate metabolic characteristics unseparated by the HPS and the mixed-score.Participants with higher HRSs had better metabolic traits than those with lower HRSs.Large interpersonal variations were also evidenced by evaluating postprandial homeostatic resiliencies for glucose,lipids and amino acids when participants had similar overall HRSs.Additionally,the HRS was positively associated with physical activity level and specific gut microbiome structure.Collectively,our HSM model might offer a novel approach to precisely define an individual’s metabolic health and nutritional capacity.

关 键 词：metabolic health TWO-DIMENSIONAL homeostatic resilience 

分 类 号：X703[环境科学与工程—环境工程]