2型糖尿病患者FIB-4及TyG指数与冠状动脉粥样硬化性心脏病的相关性分析  

The Correlation Between FIB-4,TyG Index and Coronary A therosclerotic Heart Disease in Patients with Type 2 Diabetes

作　　者：王佳琪 王禹韬 兰丽珍[1] WANG Jiaqi;WANG Yutao;LAN Lizhen(First Clinical Medical College of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一临床医学院,山西太原030001

出　　处：《标记免疫分析与临床》2025年第1期52-57,62,共7页Labeled Immunoassays and Clinical Medicine

基　　金：山西省科普宣传专项课题(编号:08776)。

摘　　要：目的 分析2型糖尿病患者中FIB-4及TyG指数与冠状动脉粥样硬化性心脏病的相关性。方法 回顾性分析2022年12月至2024年2月收住于山西医科大学第一医院全科医疗科的2型糖尿病患者,依据有无冠心病分为冠心病组(n=87)及非冠心病组(n=262),比较两组间的FIB-4及TyG水平;采用Spearman相关性分析法分析各指标间的相关性;采用Logistic回归分析法分析冠心病的危险因素;绘制受试者工作特征曲线(ROC曲线),计算曲线下面积(AUC),探究FIB-4水平对冠心病的诊断效能。结果 与非冠心病组相比,冠心病组中的FIB-4指数值较高,两组间的差异具有统计学意义(P=0.007,置信区间为95%),FIB-4水平对冠心病的诊断效能ROC曲线面积为0.633,约登指数为0.259,相对应的截断值为1.325,此时灵敏度为66.7%。结论 FIB-4指数可作为2型糖尿病患者发生冠状动脉粥样硬化性心脏病的诊断指标,而TyG指数的诊断价值仍需要大量临床研究来证明。Objective To analyze the correlation between FIB-4,TyG index and coronary atherosclerotic heart disease in type 2 diabetes patients.Methods A retrospective analysis was conducted among 482 patients with type 2 diabetes who were admitted to the General Medical Department of the First Hospital of Shanxi Medical University from December,2022 to February,2024.A cross-sectional analysis was applied for these subjects.All patients were divided into a coronary heart disase group(n=87)and a non-coronary heart disease group(n=262)according to whether there was coronary heart disease.Results Compared with the non-coronary heart disease group,the FIB-4 index value in the coronary heart disease group was significantly higher(P=0.007,confidence interval of 95%).Conclusion The FIB-4 index can be used as a diagnostic indicator for coronary atherosclerotic heart disease in patients with type 2 diabetes,while the diagnostic value of the TyG index needs further extensive clinical investigations.

关 键 词：2型糖尿病 FIB-4 TyG 冠心病 标志物 

分 类 号：R587.1[医药卫生—内分泌]