自体输血对血浆麻醉药物浓度影响的相关研究进展  

Advances in Research on the Impact of Autologous Blood Transfusion on Plasma Concentrations of Anesthetic Drugs

作　　者：王金伙 郭建荣 WANG Jinhuo;GUO Jianrong(Department of Anesthesiology and Perioperative Medicine,Shanghai Gongli Hospital,Naval MillitaryMedical University,Shanghai 200135)

机构地区：[1]海军军医大学附属公利医院麻醉与围术期医学部,上海200135

出　　处：《临床输血与检验》2025年第1期121-126,共6页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：上海市浦东新区卫生系统重点学科群建设项目(No.PWZxq2022-05)资助。

摘　　要：自体输血技术是一种解决临床用血供需矛盾和输血难题的有效方法,其类型包括稀释式、回收式和贮存式等,主要是将患者自身预先贮存的血液或失血后回收的血液在患者需要输血时进行回输。自体输血已广泛应用于临床,选择得当的自体输血技术可显著降低对异体血的需求,降低异体输血相关并发症,有效避免传染性疾病的传播。但在应用中其不可避免地引起机体一系列的病理生理变化,进而可能影响术中麻醉药物的作用,最终影响患者术后恢复质量。本文重点围绕近年来不同自体输血技术对麻醉药血浆浓度影响的相关研究进展做一综述。Objective Autologous blood transfusion technology serves as an efficacious solution to the clinical dilemma of blood supply and demand,as well as the challenges associated with transfusion therapy.The techniques encompass various methods,including preoperative hemodilution,intraoperative salvage,and blood storage.The core principle involves the reinfusion of the patient's own blood,which may have been banked in advance or retrieved post-hemorrhage,when transfusion is necessitated.The application of autologous blood transfusion in clinical practice has been widespread,and these techniques can markedly reduce the reliance on allogeneic blood,which not only minimizes the risks of allogeneic transfusion-related complications but also effectively circumvents the transmission of infectious diseases.Nevertheless,the implementation of autologous blood transfusion inevitably induces a cascade of pathophysiological alterations within the body.These changes have the potential to influence the pharmacodynamic profile of anesthetic agents administered during surgery,thereby impacting the process of postoperative recovery.This review focuses on recent advancements in the impact of different autologous blood transfusion techniques on the plasma concentrations of anesthetic drugs.

关 键 词：自体输血 血药浓度 麻醉药 

分 类 号：R457.1[医药卫生—治疗学]