胫骨骨膜侧向牵张术联合复方紫银软膏治疗糖尿病足的临床疗效  

Clinical effect of tibial periosteal lateral distraction combined with compound Ziyin ointment in the treatment of diabetic foot

作　　者：梁其国 邓福临 赵遵江 关继奎 吕大伦 Liang Qiguo;Deng Fulin;Zhao Zunjiang;Guan Jikui;Lyu Dalun(Department of Burns and Plastic Surgery,the First People′s Hospital of Wuhu,Wuhu 241000,China;Department of Burns and Plastic Surgery,the First Affiliated Hospital of Wannan Medical College,Wuhu 241000,China)

机构地区：[1]芜湖市第一人民医院烧伤整形科,芜湖241000 [2]皖南医学院第一附属医院烧伤整形外科,芜湖241000

出　　处：《中国医师杂志》2025年第1期81-85,共5页Journal of Chinese Physician

基　　金：安徽省高校自然科学研究项目(2023A040248);芜湖市科技局重点研发与成果转化项目(2023yf100)。

摘　　要：目的探讨胫骨骨膜侧向牵张术联合复方紫银软膏治疗糖尿病足的临床疗效。方法前瞻性选择2022年7月—2023年9月于芜湖市第一人民医院就诊的62例糖尿病足患者,按随机数字表法分成常规组与联合组,每组31例。常规组采用胫骨骨膜侧向牵张术治疗,联合组采用胫骨骨膜侧向牵张术联合复方紫银软膏治疗,均持续治疗2周。观察两组患者治疗前后的中医证候积分、血清炎症因子和生长因子水平、足温、趾端血氧饱和度、疼痛与生活质量评分、临床疗效和并发症。结果治疗后,两组中医证候积分、血清炎症因子水平、疼痛评分均较治疗前降低,血清生长因子水平、生活质量评分、足温、趾端血氧饱和度均较治疗前升高(均P<0.05)。治疗后,联合组疼痛评分、中医主症评分、中医次症评分、炎症因子水平均低于常规组(均P<0.05),血清生长因子水平、生活质量评分及足温、趾端血氧饱和度均高于常规组(均P<0.05)。联合组患者治疗总有效率高于常规组[93.55%(29/31)vs 70.97%(22/31),P<0.05];两组不良反应总发生率差异无统计学意义(P>0.05)。结论胫骨骨膜侧向牵张术联合复方紫银软膏能够改善糖尿病足患者血清炎症因子、生长因子水平及足温、趾端血氧饱和度,降低中医证候积分及减轻疼痛程度,提高患者生活质量及临床疗效,安全性较高。Objective To investigate the clinical effect of tibial periosteal lateral distraction combined with compound Ziyin ointment in the treatment of diabetic foot.MethodsA total of 62 patients with diabetic foot treated in the First People′s Hospital of Wuhu from July 2022 to September 2023 were prospectively selected and divided into routine group and combination group according to random number table method,with 31 cases in each group.The conventional group was treated with tibial periosteal lateral stretch,and the combined group was treated with tibial periosteal lateral distraction combined with compound Ziyin ointment,and the treatment lasted for 2 weeks.Traditional Chinese Medicine(TCM)syndrome scores,serum inflammatory factors,growth factors,foot temperature,toe oxygen saturation,pain and quality of life scores,clinical efficacy and complications were observed before and after treatment in the two groups.ResultsAfter treatment,TCM syndrome score,serum inflammatory factor level and pain score were lower than before treatment,serum growth factor level,life quality score,foot temperature and toe end blood oxygen saturation were higher than before treatment(all P<0.05).After treatment,the pain score,TCM main disease score,TCM secondary disease score and inflammatory factor levels in the combined group were lower than those in the conventional group(all P<0.05),and the serum growth factor level,life quality score,foot temperature and toe end blood oxygen saturation were higher than those in the conventional group(all P<0.05).The total effective rate of combined group was higher than that of conventional group[93.55%(29/31)vs 70.97%(22/31),P<0.05].There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).ConclusionsTibial periosteal lateral distraction combined with compound Ziyin ointment can improve the levels of serum inflammatory factors,growth factors,foot temperature and toe oxygen saturation,reduce TCM syndrome score and relieve pain degree,improve patient

关 键 词：糖尿病足 胫骨骨膜侧向牵张术 复方紫银软膏 

分 类 号：R587.2[医药卫生—内分泌]