盐酸羟考酮注射液复合右美托咪定在磁波刀治疗妇科疾病中的应用  

Application of Oxycodone Hydrochloride Injection combined with Dexmedetomidine in the treatment of gynecological diseases with magnetic wave knife

作　　者：张东旭 李海超 王莉 刘建 ZHANG Dongxu;LI Haichao;WANG Li;LIU Jian(Anesthesia Surgery Center,Foresea Life Insurance Guangzhou General Hospital,Guangdong Province,Guangzhou 511330,China)

机构地区：[1]前海人寿广州总医院麻醉手术中心,广东广州511330

出　　处：《中国当代医药》2025年第3期93-96,共4页China Modern Medicine

摘　　要：目的探讨盐酸羟考酮注射液复合右美托咪定在体部磁波刀治疗子宫肌瘤及子宫腺肌症的效果。方法选取2020年9月至2024年1月前海人寿广州总医院收治的100例妇科疾病患者作为研究对象,按照随机数字表法分为盐酸羟考酮组(Q组)与舒芬太尼组(S组),每组50例。Q组采用静注羟考酮复合右美托咪定,S组采用静注舒芬太尼复合右美托咪定。比较两组患者俯卧于磁波刀治疗床摆好体位后(T_(0))、治疗开始时(T_(1))、治疗开始后30 min(T_(2))、手术结束时(T_(3))、入复苏室观察30 min后(T_(4))的平均动脉压(MAP),心率(HR),血氧饱和度(SpO_(2)),T_(0)、T_(3)、T_(4)的视觉模拟评分法(VAS)评分以及不良反应发生率。结果两组患者MAP、HR、SpO_(2)时间、组间、交互作用比较,差异无统计学意义(P>0.05);两组患者T_(0)、T_(1)、T_(2)、T_(3)、T_(4)时MAP、HR、SpO_(2)比较,差异无统计学意义(P>0.05)。Q组不良反应总发生率低于S组,差异有统计学意义(P<0.05)。T_(0)时,两组患者VAS评分比较,差异无统计学意义(P>0.05);T_(3)、T_(4)时,两组患者VAS评分均低于本组T_(0)时,且Q组VAS评分低于S组,差异有统计学意义(P<0.05);两组患者的VAS评分时间、组间、交互作用比较,差异有统计学意义(P<0.05)。结论盐酸羟考酮注射液复合右美托咪定可以安全有效地在体部磁波刀治疗子宫肌瘤及子宫腺肌病中得到应用,镇痛效果好,患者舒适度高,不良反应少。Objective To investigate the effect of Oxycodone Hydrochloride Injection combined with Dexmedetomidine in the treatment of uterine fibroids and uterine adenomyosis with magnetic wave knife.Methods A total of 100 patients with gynecological diseases admitted to Foresea Life Insurance Guangzhou General Hospital from September 2020 to January 2024 were selected as the research objects,and they were divided into Oxycodone Hydrochloride Injection group(group Q)and Sufentanil group(group S)according to random number table method,with 50 cases in each group.Group Q was administered Oxycodone Hydrochloride Injection combined with Dexmedetomidine,group S was administered Sufentanil combined with Dexmedetomidine.The mean arterial pressure(MAP),heart rate(HR)and blood oxygen saturation(SpO_(2))of the two groups were compared after lying prone on the magnetic wave knife treatment table(T_(0)),at the beginning of treatment(T_(1)),30 min after treatment(T_(2)),at the end of surgery(T_(3)),and 30 min after observation in the resuscitation room(T_(4)),visual analogue scale(VAS)scores of T_(0),T_(3),T_(4) and incidence of adverse reactions.Results There were no significant differences in MAP,HR,SpO_(2) time,inter-group and interaction between the two groups(P>0.05).There were no significant differences in MAP,HR and SpO_(2) at T_(0),T_(1),T_(2),T_(3) and T_(4) between the two groups(P>0.05).The total incidence of adverse reactions in group Q was lower than that in group S,and the difference was statistically significant(P<0.05).At T_(0),there were no significant differences in VAS scores between the two groups(P>0.05).At T_(3) and T_(4),VAS scores of two groups were lower than those at T_(0),and VAS scores of Q group were lower than those of S group,the differences were statistically significant(P<0.05).There were significant differences in VAS scores time,inter-group and interaction between the two groups(P<0.05).Conclusion Oxycodone Hydrochloride Injection combined with Dexmedetomidine can be safely and effectively used in the

关 键 词：盐酸羟考酮注射液 右美托咪定 磁波刀 子宫肌瘤 子宫腺肌病 

分 类 号：R614[医药卫生—麻醉学]