去铁蛋白载体负载药物策略及其抗癌应用进展  

Advancements in Drug Delivery Strategies Utilizing Apoferritin as a Carrier and Their Anticancer Practical Implementations

作　　者：徐莉 朱红旭 王子涵 贾思宇 陈慧 蒋欣怡 季鹏 XU Li;ZHU Hong-xu;WANG Zi-han;JIA Si-yu;CHEN Hui;JIANG Xin-yi;JI Peng(Liaoning Vocational College of Medicine,Liaoning 110101,China;College of Pharmacy and Chemistry&Chemical Engineering,Taizhou University,Taizhou 225300,China;Liangzhu Laboratory,Medical Center,Zhejiang University Hangzhou 311121,China)

机构地区：[1]辽宁医药职业学院,辽宁沈阳110101 [2]泰州学院医药与化学化工学院,江苏泰州225300 [3]浙江大学医学中心良渚实验室,浙江杭州311121

出　　处：《安徽化工》2024年第6期16-20,共5页Anhui Chemical Industry

基　　金：辽宁省教育厅基本科研项目(青年项目)(LJKQZ20222376);辽宁医药职业学院兴辽卓越建设特色项目课题;浙江省博士后科研项目择优资助(ZJ2023083);泰州学院2024年校级大学生创新创业训练计划项目(cx240116x,cy240117)。

摘　　要：铁蛋白纳米是一种天然的纳米粒子,由于其具有生物相容性良好和特定靶向活性等特性,被广泛关注,其在生物医学领域具有潜在的应用前景。回顾了铁蛋白纳米笼的结构特点,载体递送的优势,可负载药物的种类,载药技术及其在肝癌、乳腺癌和胶质瘤中的应用进展,并对其应用前景进行了总结与展望。Ferritin nanocages,as natural nanoparticles,have garnered considerable interest within the biomedical domain owing to their notable attributes including excellent biocompatibility and targeted delivery capabilities.This paper presents a comprehensive review of the structural characteristics of ferritin nanocages,their utility as drug carriers,the spectrum of drugs amenable to encapsulation,diverse drug-loading methodologies,and the advancements in their utilization across he⁃patocellular carcinoma,breast cancer,and glioma applications.

关 键 词：去铁蛋白 被动负载法 尿素梯度法 温度调控法 抗癌 

分 类 号：TQ460[化学工程—制药化工]