LncRNA RMST在胃癌组织中的表达及与诊断和预后的关系  

The role of LncRNA RMST in gastric cancer:Expression levels,diagnostic value,and prognostic implicationssion

作　　者：王丹萍 蔡煜锋 胡德华[2] 张亮[1] WANG Danping;CAI Yufeng;HU Dehua;ZHANG Liang(Department of Oncology,Nantong First People's Hospital(Affiliated Hospital 2 of Nantong University),Nantong 226006,Jiangsu,China;不详)

机构地区：[1]南通市第一人民医院(南通大学第二附属医院)肿瘤科,江苏南通226006 [2]中南大学生命科学学院,湖南长沙410078

出　　处：《实用医学杂志》2025年第3期409-413,共5页The Journal of Practical Medicine

基　　金：湖南省重点领域研发计划(国际与区域合作)(编号:2021WK2003);南通市基础科学研究和社会民生科技计划项目(编号:MSZ2022041)。

摘　　要：目的探索长链非编码RNA(LncRNA)横纹肌肉瘤相关转录物-2(RMST)在胃癌中的表达和在诊断及预后中的价值。方法收集分析92例胃癌患者的肿瘤组织和相邻正常组织,通过反转录定量聚合酶链反应检测这些组织中LncRNA RMST的表达。采用受试者工作特征曲线分析评估LncRNA RMST对胃癌的诊断价值。绘制生存曲线评估LncRNA RMST在胃癌预后中的价值。结果LncRNA RMST在胃癌组织中的表达显著低于正常组织。进一步分析发现,LncRNA RMST的表达水平随胃癌分期的增加逐渐下降,并且与肿瘤最大径、TNM分期及淋巴结转移显著相关(P<0.05),而与患者的年龄和性别无关。ROC曲线分析显示LncRNA RMST在胃癌的诊断中具有较高的价值,曲线下面积为0.76(95%CI:0.69~0.83,P<0.01),敏感度和特异度分别为70.31%和71.56%。生存分析表明,LncRNA RMST高表达的患者总体生存率显著高于低表达患者。结论LncRNA RMST在胃癌的发生、进展和预后中具有重要作用,可能作为胃癌诊断和预后的潜在生物标志物,为临床筛查和治疗提供新的思路。Objective To investigate the expression of LncRNA RMST in gastric cancer and its value in diagnosis and prognosis.Methods Tumor and adjacent normal tissues were collected and analyzed from 92 gastric cancer patients.The expression of LncRNA RMST in these tissues was measured using RT-qPCR.ROC curve analysis was performed to evaluate the diagnostic value of LncRNA RMST for gastric cancer.Survival curves were plotted to assess the prognostic significance of LncRNA RMST in gastric cancer.Results LncRNA RMST expression was significantly lower in gastric cancer tissues than in normal tissues.Further analysis revealed that LncRNA RMST expression levels decreased progressively with advancing cancer stages and were significantly correlated with tumor size,TNM staging,and lymph node metastasis(P<0.05),with no significant correlation with patient age or gender.Additionally,ROC curve analysis indicated that LncRNA RMST has substantial diagnostic value in gastric cancer,with AUC of 0.76(95%CI:0.69~0.83,P<0.01),sensitivity of 70.31%,and specificity of 71.56%.Survival analysis showed that patients with high LncRNA RMST expression had significantly higher overall survival rates than those with low expression.Conclusion LncRNA RMST plays a critical role in the occurrence,progression,and prognosis of gastric cancer.It may serve as a potential biomarker for the diagnosis and prognosis of gastric cancer,offering new insights for clinical screening and therapeutic strategies.

关 键 词：胃癌 长链非编码RNA横纹肌肉瘤相关转录物-2 诊断 预后 

分 类 号：R656.6[医药卫生—外科学]