血管基质片段在整形外科领域中的应用研究进展  

Research progress on application of stromal vascular fractionin plastic surgery

作　　者：陈盈盈 郭治宏 刘德伍[1] CHEN Yingying;GUO Zhihong;LIU Dewu(Medical Center for Burns,Department of Plastic Surgery and Wound Repair,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi,China)

机构地区：[1]南昌大学第一附属医院烧伤整形与创面修复医学中心,江西南昌330006

出　　处：《实用医学杂志》2025年第3期442-446,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:82160378,81860340)。

摘　　要：血管基质片段(stromal vascular fraction,SVF)是脂肪组织通过酶和非酶技术,手动或在自动封闭系统中分离处理后所获得的细胞混合物,主要包括脂肪源性干细胞,成纤维细胞、免疫和内皮细胞以及周细胞。因其促进创面愈合及组织修复的作用被广泛应用。近年来,SVF开始用于促进瘢痕修复、对抗皮肤衰老、促进毛发再生及提高脂肪移植的存活率等方面,并取得了显著疗效。但目前缺乏对SVF在整形外科领域临床研究成果的有效整合。本文就SVF的定义、作用机制和在整形外科领域的临床应用展开综述,以期探讨SVF作为组织再生修复治疗新策略在整形外科领域广泛应用的可能性,并为SVF研究的深入开展指明方向。Derived from adipose tissue,stromal vascular fraction(SVF)contains heterogeneous cell populations including adipose-derived stem cells(ADSCs),adipose precursor cells,endothelial cells,and macrophages,which can be isolated manually or in an automated closed system by enzymatic and non-enzymatic technique.SVF has been widely applied in various fields because of its role in wound healing and tissue repair,and in recent years,SVF has been applied to promote their pair of scar,skin rejuvenation and hair regeneration,and improve the survival of fat grafting,which has achieved significant efficacy.However,there is a lack of effective integration of clinical research on SVF in the field of plastic surgery.This paper provides a systematic review of the definition,mechanism and applications of SVF in order to investigate the potential of SVF as a novel strategy for tissue regeneration and repair treatment in the field of plastic surgery and to point out the direction for further advancements in SVF research.

关 键 词：血管基质片段 整形外科 瘢痕 脂肪移植 皮肤年轻化 脱发 

分 类 号：R622.9[医药卫生—整形外科]