Health risks of rare earth elements exposure:Impact on mitochondrial DNA copy number and micronucleus frequency  

作　　者：Shiyi Hong Yali Zhang Qiaojian Zhang Zekang Su Guiping Hu Li Wang Shanfa Yu Xiaojun Zhu Guang Jia 

机构地区：[1]Department of Occupational and Environmental Health Sciences,School of Public Health,Peking University,Beijing 100083,China [2]School of Engineering Medicine and Beijing Advanced Innovation Center for Big Data-Based Precision Medicine,Beihang University,Beijing 100083,China [3]Department of Toxicology,School of Public Health,Baotou Medical College,Baotou,Inner Mongolia 014040,China [4]Henan Institute for Occupational Medicine,Zhengzhou 450052,China [5]National Center for Occupational Safety and Health,Beijing 102308,China [6]Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety,School of Public Health,Peking University,Beijing 100083,China

出　　处：《Journal of Environmental Sciences》2025年第5期150-160,共11页环境科学学报(英文版)

基　　金：supported by the National Natural Science Foundation of China(Nos.U200420282273603 and 82003427).

摘　　要：Toxic effects in terms of mitochondria and hereditary substances have been characterized in vitro for individual rare earth elements,while,the joint effects of mixed elements exposure in the population remain ambiguous.Based on the Occupational Chromate Exposure Dynamic Cohort of China,this study investigated the relationship between 15 blood rare earth elements(cerium,dysprosium,erbium,europium,gadolinium,holmium,lanthanum,lutetium,neodymium,praseodymium,samarium,terbium,thulium,yttrium,and ytterbium)and mitochondrial DNA copy number(MtDNACN)as well as peripheral blood lymphocyte micronucleus frequency(MNF).The elastic net was used to select elements highly correlated with effect indicators,whose dose-response relationships were further illustrated by restricted cubic splines.Bayesian kernel regressionwas employed to explore the combined effects of elements and the contributions of single element.The results showed that most rare earth elementswere positively correlatedwith effect indicators,with yttrium showing the strongest association(β(95%CI):0.139(0.1089–0.189)for MtDNACN,0.937(0.345–1.684)for MNF).In the mixed exposure model,with the exposure level fixed at the 50th percentile as the reference,the effect estimates on MtDNACN and MNF increased by 0.228 and 0.598 units,respectively,at the 75th percentile.The single effect analysis implied that yttrium,lanthanum and terbium contributed the most to the elevation of MtDNACN,while yttrium posed the highest risk for genetic damage,accordingly,we provided recommendations to prioritize these elements of concern.In addition,we observed a chief mediating effect of MtDNACN on the elevation of MNF caused by lanthanum,whereas further mechanistic exploration is required to confirm this finding.

关 键 词：Rare earth elements Mitochondrial DNA copy number Micronucleus frequency Mixed effect 

分 类 号：O61[理学—无机化学]