Associations of multiple metals exposure with immunoglobulin levels in pregnant women:Hangzhou Birth Cohort Study  

作　　者：Jiena Zhou Lanfei Jin Yexinyi Zhou Kunhong Zhong Kegui Huang Qi Zhang Jun Tang Xue Zhang Lihe Peng Shuai Li Na Lv Dongdong Yu Qinheng Zhu Jing Guo Qiong Luo Guangdi Chen 

机构地区：[1]Department of Public Health,and Key Laboratory of Reproductive Genetics(Ministry of Education),Women’s Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China [2]Department of Clinical Laboratory,Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310018,China [3]Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China [4]Jiashan County Center for Disease Control and Prevention,Jiashan,Zhejiang 314199,China [5]Department of Clinical Laboratory,Women’s Hospital,Zhejiang University School of Medicine,Hangzhou 310020,China [6]Department of Obstetrics,Women’s Hospital,Zhejiang University School of Medicine,Hangzhou 310020,China

出　　处：《Journal of Environmental Sciences》2025年第5期560-572,共13页环境科学学报(英文版)

基　　金：supported by the National Natural Science Foundation of China(No.U22A20358);Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents(No.2020-18).

摘　　要：Metal may affect maternal immune function,but few epidemiological studies have reported the associations between multiple-metal exposure and maternal immunoglobulin(Ig)levels.Based on the Hangzhou Birth Cohort Study,1059 participants were included,and eleven metals in whole blood samples and serum IgA,IgG,IgE and IgM levels were measured.Linear regression,quantile-based g-computation(QGC),and Bayesian kernel machine regression(BKMR)models were used to evaluate the associations.Compared with the first tertile of metal levels,arsenic(As)was negatively associated with IgE(β=-0.25,95%confidence interval(CI)=-0.48 to-0.02).Moreover,significant associations of manganese(Mn)with IgA,IgG and IgM were demonstrated(β=0.10,95%CI=0.04 to 0.18;β=0.07,95%CI=0.03 to 0.12;β=0.10,95%CI=0.03 to 0.18,respectively).Cadmium(Cd)were associated with higher levels of IgM.QGC models showed the positive association of the metalmixtures with IgA and IgG,with Mn playing amajor role.Mn and Cd had positive contributions to IgM,while As had negative contributions to IgE.In the BKMR models,the latent continuous outcomes of IgA and IgG showed a significant increase when all the metals were at their 60th percentile or above compared to those at their 50th percentile.Therefore,exposure to metals was associated with maternal Igs,and mainly showed that Mn was associated with increased levels of IgA,IgG and IgM,and As was associated with low IgE levels.

关 键 词：METALS IMMUNOGLOBULIN Pregnant woman Quantile-based g-computation (QGC) Bayesian kernel machine regression (BKMR) 

分 类 号：R72[医药卫生—儿科]