血清铁蛋白联合红细胞参数检测对血液透析患者缺铁性贫血的诊断价值  

Diagnostic value of serum ferritin combined with erythrocyte parameters for iron-deficiency anemia in patients undergoing hemodialysis

作　　者：单永强[1] 徐耀华 杜春红[1] Shan Yongqiang;Xu Yaohua;Du Chunhong(Department of Blood Transfusion,Tianjin Medical University General Hospital,Tianjin300050,China)

机构地区：[1]天津医科大学总医院输血科,天津300050

出　　处：《中国基层医药》2025年第1期42-46,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察血清铁蛋白联合红细胞参数检测对血液透析患者缺铁性贫血的诊断价值。方法选取天津医科大学总医院2021年1月至2023年12月收治的血液透析贫血患者100例为研究对象,根据患者是否为缺铁性贫血分为缺铁性贫血组(37例)和铁正常贫血组(63例)。对比两组患者的血清铁蛋白(SF)水平、红细胞参数[红细胞计数(RBC)、血红蛋白(Hb)、红细胞容积分布宽度(RDW)、红细胞比容(HCT)]。采用受试者工作特征(ROC)曲线分析血清铁蛋白联合红细胞参数对血液透析患者缺铁性贫血的诊断价值。结果缺铁性贫血组患者的SF、Hb、HCT分别为(16.79±3.55)μg/L、(96.23±5.00)g/L、0.29±0.04,均低于铁正常贫血组的(25.45±5.85)μg/L、(103.48±5.59)g/L、0.33±0.04(t=8.15、6.50、5.47,均P<0.001);而RDW[(15.28±2.37)%]高于铁正常贫血组的(12.62±2.41)%(t=-5.36,P<0.001);缺铁性贫血组的RBC[(3.75±0.57)×10^(12)/L]与铁正常贫血组[(3.86±0.43)×10^(12)/L]差异无统计学意义(t=1.02,P>0.05)。经ROC分析,SF、Hb、HCT、RDW对血液透析患者缺铁性贫血诊断的曲线下面积分别为0.888、0.841、0.787、0.777,敏感度分别为91.89%、81.08%、70.27%、81.08%,特异度分别为79.37%、80.95%、76.19%、68.25%。结论血清铁蛋白联合红细胞参数检测对血液透析患者缺铁性贫血的诊断价值较高,可为缺铁性贫血的早期诊疗提供参考依据。ObjectiveTo investigate the diagnostic value of serum ferritin(SF)combined with erythrocyte parameters for iron-deficiency anemia in patients undergoing hemodialysis.MethodsA total of 100 patients with anemia undergoing hemodialysis at Tianjin Medical University General Hospital from January 2021 to December 2023 were included in this study.Based on the types of anemia,the patients were divided into two groups:the iron-deficiency anemia group(n=37)and the iron-normal anemia group(n=63).The SF levels and erythrocyte parameters[red blood cell count,hemoglobin(Hb),red blood cell distribution width(RDW),and hematocrit(HCT)]were compared between the two groups.The diagnostic value of SF combined with erythrocyte parameters for identifying iron-deficiency anemia in patients undergoing hemodialysis was analyzed using receiver operating characteristic curves.ResultsThe SF and HB levels as well as HCT in the iron-deficiency anemia group were(16.79±3.55)μg/L,(96.23±5.00)g/L,and 0.29±0.04,respectively.These values were significantly lower than those in the iron-normal anemia group[(25.45±5.85)μg/L,(103.48±5.59)g/L,0.33±0.04,t=8.15,6.50,5.47,all P<0.001].The RDW in the iron-deficiency anemia group was(15.28±2.37)%,which was significantly higher than that in the iron-normal anemia group[(12.62±2.41)%,t=-5.36,P<0.001].There was no significant statistical difference in red blood cell count between the iron-deficiency anemia group[(3.75±0.57)×10^(12)/L]and the iron-normal anemia group[(3.86±0.43)×10^(12)/L,t=1.02,P>0.05].According to receiver operating characteristic analysis,the areas under the curve for SF,Hb,HCT,and RDW in the diagnosis of iron-deficiency anemia in patients undergoing hemodialysis were 0.888,0.841,0.787,and 0.777,respectively.The sensitivities were 91.89%,81.08%,70.27%,and 81.08%,respectively,while the specificities were 79.37%,80.95%,76.19%,and 68.25%,respectively.ConclusionsThe diagnostic value of SF combined with erythrocyte parameters is high for identifying iron-deficiency anemia in patient

关 键 词：肾透析 贫血 缺铁性 铁蛋白质类 红细胞计数 血红蛋白类 血细胞比容 诊断 

分 类 号：R692.5[医药卫生—泌尿科学] R556.3[医药卫生—外科学]