藏族大学生乙型肝炎血清学标志物水平及其与HBV-DNA载量的关系研究  

Levels of serological markers of hepatitis B virus in Tibetan college students and their relationship with HBV-DNA loads

作　　者：高芬 次曲 郝小康 王宇鹤[1] 刘欣 赵晓婕 杜恬恬 薛佳佳 贺娜 周娟 Gao Fen;Ci Qu;Hao Xiaokang;Wang Yuhe;Liu Xin;Zhao Xiaojie;Du Tiantian;Xue Jiajia;He Na;Zhou Juan(Department of Laboratory Medicine,Affiliated Hospital of Xizang Minzu University,Xianyang712082,Shaanxi Province,China;Department of Laboratory Medicine,Third People's Hospital of Xizang Autonomous Region,Lasa 850000,Xizang Autonomous Region,China;Department of Critical Care Medicine,Affiliated Hospital of Xizang Minzu University,Xianyang 712082,Xizang Autonomous Region,China)

机构地区：[1]西藏民族大学附属医院检验科,咸阳712082 [2]西藏自治区第三人民医院检验科,拉萨850000 [3]西藏民族大学附属医院重症医学科,咸阳712082

出　　处：《中国基层医药》2025年第1期60-64,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：西藏自治区自然科学基金[(XZ2019ZRG-30(Z))]。

摘　　要：目的了解藏族大学生乙型肝炎病毒(HBV)血清学标志物检测情况及其与乙型肝炎病毒脱氧核糖核酸(HBV-DNA)载量的关系。方法采用横断面研究,回顾性分析西藏民族大学附属医院2021年6月1日至2022年6月1日就诊和体检的藏族大学生1514例的资料,分析藏族大学生HBV感染情况、乙型肝炎标志物主要流行模式与HBV-DNA的关系。结果1514例藏族大学生乙型肝炎表面抗原(HBsAg)阳性率为6.7%(101/1514),乙型肝炎表面抗体(HBsAb)阳性率为42.2%(639/1514),感染HBV血清抗体模式主要以大三阳模式为主(占48.5%),大三阳模式的HBV-DNA阳性率及病毒载量均高于其他模式,差异有统计学意义(χ^(2)=8.70,P<0.05)。结论藏族大学生HBV感染率为6.7%,感染模式主要以大三阳为主,HBV-DNA总体阳性率高达87.0%且载量较高。ObjectiveTo investigate the detection status of serological markers for hepatitis B virus(HBV)among Tibetan college students and their relationship with HBV-deoxyribonucleic acid(DNA)load.MethodsA cross-sectional study was carried out to retrospectively analyze data from 1514 Tibetan college students who visited the Affiliated Hospital of Xizang Minzu University for consultations or health examinations between June 1,2021 and June 1,2022.The prevalence of HBV infection among these students was analyzed,the primary epidemiological patterns of HBV markers were identified,and their relationship with HBV-DNA load was determined.ResultsThe positive rate of hepatitis B surface antigen(HBsAg)among the 1514 Tibetan college students was 6.7%(101/1514),while the positive rate for Hepatitis B surface antibody(HBsAb)was 42.2%(639/1514).The primary serological pattern of HBV infection consisted of positive results for HBsAg,HBeAg,and HBcAb,which accounted for 48.5%of cases.This pattern showed significantly higher rates of HBV-DNA positivity and elevated viral load compared with other serological patterns(χ^(2)=8.70,P<0.05).ConclusionsThe HBV infection rate among Tibetan college students is 6.7%.The primary infection pattern is characterized by positive tests for HBsAg,HBeAg,and HBcAb,with an HBV-DNA positivity rate as high as 87.0%and elevated viral loads.

关 键 词：乙型肝炎病毒 流行病学研究 乙型肝炎表面抗原 乙型肝炎抗体 脱氧核糖核酸酶类 

分 类 号：R512.62[医药卫生—内科学]