双歧杆菌三联活菌胶囊辅治轻症胆源性急性胰腺炎的疗效及对炎性因子、肠屏障功能、免疫功能的影响  

The efficacy of Bifidobacterium triple viable capsule in the adjuvant treatment of mild biliary acute pancreatitis and its influence on inflammatory factors,intestinal barrier function and immune function

作　　者：朱恒波 潘英[1] 刘留 汪浩鹏 陈鹏[1] Zhu Hengbo;Pan Ying;Liu Liu;Wang Haopeng;Chen Peng(Department of Gastroenterology,Fourth Affiliated Hospital of Nanjing Medical University,Jiangsu Province,Nanjing 210000,China)

机构地区：[1]南京医科大学第四附属医院消化内科,南京210000

出　　处：《疑难病杂志》2025年第2期170-174,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：江苏省卫生健康委科研项目(BJ22009)。

摘　　要：目的探讨双歧杆菌三联活菌胶囊辅助治疗轻症胆源性急性胰腺炎(BAP)的疗效以及对炎性因子、肠屏障功能、免疫功能的影响。方法纳入2019年2月—2023年10月南京医科大学第四附属医院消化内科收治的轻症BAP患者140例,以随机数字表法分为观察组和对照组各70例。对照组采取常规治疗,观察组在对照组基础上联合双歧杆菌三联活菌胶囊辅助治疗。治疗1周后,分析2组患者的临床疗效;比较2组患者腹痛和腹胀消失时间;并检测治疗前后患者血清炎性因子[C反应蛋白(CRP)、白介素-6(IL-6)、白细胞数(WBC)]、肠屏障功能[内毒素、二胺氧化酶(DAO)、D-乳酸]、胰腺功能[淀粉酶(AMY)、脂肪酶(LIPA)]以及免疫球蛋白(IgG、IgA和IgM)的水平。结果治疗1周后,观察组总有效率为92.86%,高于对照组的80.00%(χ^(2)/P=4.933/0.026)。治疗后观察组腹痛和腹胀消失时间均明显短于对照组(t/P=8.117/<0.001、6.857/<0.001)。治疗后2组患者血清CRP、IL-6、WBC、内毒素、DAO、D-乳酸、AMY、LIPA水平均明显低于治疗前,且观察组低于对照组(t/P=4.087/<0.001,8.654/<0.001,12.334/<0.001,15.503/<0.001,13.900/<0.001,14.254/<0.001,26.761/<0.001,12.610/<0.001),而IgA、IgG和IgM水平明显升高,且观察组高于对照组(t/P=3.244/<0.001,7.351/<0.001,10.249/<0.001)。结论双歧杆菌三联活菌胶囊辅助治疗能提高轻症BAP疗效,抑制炎性反应,调节肠屏障功能,恢复免疫功能。Objective To explore the therapeutic effect of Bifid as an adjuvant therapy for mild biliary acute pancreatitis(BAP)and its impacts on inflammatory factors,intestinal function,and immune function.Methods A total of 140 mild BAP patients treated in our hospital from February 2019 to October 2023 were collected and randomly separated into a treatment group and a reference group,with 70 cases in each group.The reference group received routine treatment,while the treatment group received adjuvant treatment with Bifid(bifid triple viable capsule)in addition to the reference group.The clinical efficacy of two groups was analyzed.The relief time of abdominal pain and relief time of bloating were compared between the two groups.The levels of C-reactive protein(CRP),interleukin-6(IL-6),white blood cell count(WBC),endotoxins,diamine oxidase(DAO),D-lactate,amylase(AMY),lipase(LIPA),and immunoglobulins(IgG,IgA,and IgM)were detected before and after treatment.Results The total effective rate of the treatment group was 92.86%,which was obviously better than the reference group of 80.00%(χ^(2)/P=4.933/0.026).After treatment,the disappearance time of abdominal pain and bloating in the treatment group were obviously shorter than those in the reference group(t/P=8.117/<0.001,6.857/<0.001).The levels of serum CRP,IL-6,WBC,endotoxin,DAO,D-lactate,AMY,LIPA,IgG,IgA,and IgM in the two groups before treatment were not statistically obvious(P>0.05).After treatment,the levels of CRP,IL-6,WBC,endotoxin,DAO,D-lactate,AMY,and LIPA in both groups were obviously lower than before treatment.Compared with the reference group,the difference in the treatment group was more obvious(t/P=4.087/<0.001,8.654/<0.001,12.334/<0.001,15.503/<0.001,13.900/<0.001,14.254/<0.001,26.761/<0.001,12.610/<0.001),while the levels of IgA,IgG,and IgM were obviously increased,and the treatment group were higher than the reference group(t/P=3.244/<0.001,7.351/<0.001,10.249/<0.001).Conclusion Bifid adjuvant therapy can improve the efficacy of mild BAP,inhibit inflammatio

关 键 词：轻症胆源性急性胰腺炎 双歧杆菌三联活菌胶囊 肠屏障功能 炎性因子 免疫功能 

分 类 号：R453.9[医药卫生—治疗学] R576[医药卫生—临床医学]