中重度OSAHS患者血清神经肽Y及人生长激素释放多肽变化与认知功能的关系  

Relationship between changes of serum neuropeptide Y,human growth hormone releasing polypeptide and cognitive function in patients with moderate to severe OSAHS

作　　者：周荣 周娟[2] 庄汉 张其昌 ZHOU Rong;ZHOU Juan;ZHUANG Han(Department of Otolaryngology,Suqian Hospital of Nanjing Gulou Hospital Group/Suqian Hospital Affiliated to Xuzhou Medical University,Suqian Jiangsu 223800,China;Department of Geriatrics,Suqian Hospital of Jiangsu Provincial People's Hospital,Suqian Jiangsu 223800,China)

机构地区：[1]南京鼓楼医院集团宿迁医院/徐州医科大学附属宿迁医院耳鼻咽喉科,江苏宿迁223800 [2]江苏省人民医院宿迁医院老年医学科,江苏宿迁223800

出　　处：《临床和实验医学杂志》2025年第2期188-191,共4页Journal of Clinical and Experimental Medicine

基　　金：江苏省卫生健康行业科研项目(编号:20A2050736)。

摘　　要：目的研究讨中重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清神经肽Y(NPY)、人生长激素释放多肽Ghrelin(GHRP-Ghrelin)水平的变化及其与认知功能的相关性。方法回顾性选取2023年1月至2024年1月入南京鼓楼医院集团宿迁医院的80例OSAHS患者,参考疾病严重程度划分为OSAHS中度组(n=20)与OSAHS重度组(n=60);同时选取同一时期诊治的80例单纯鼾症患者,设为鼾症组。比较3组患者血清NPY、GHRP-Ghrelin水平与简易智力状态检查量表(MMSE)、蒙特利尔认知评估表(MoCA)评分,同时分析中重度OSAHS患者NPY、GHRP-Ghrelin水平变化与其认知功能相关性。结果(1)较鼾症组[(474.07±66.34)、(1019.39±151.34)ng/L],NPY水平[(542.07±45.48)、(580.14±48.63)ng/L]均更高,OSAHS中度组、重度组GHRP-Ghrelin水平[(800.02±135.47)、(736.24±147.65)ng/L]均更低,差异均有统计学意义(P<0.05);较OSAHS中度组,OSAHS重度组NPY水平更高,GHRP-Ghrelin水平更低,差异均有统计学意义(P<0.05)。(2)较鼾症组[(28.24±0.98)分],OSAHS中度组、重度组MoCA总评分[(27.96±0.79)、(26.81±0.67)分]更低,且OSAHS重度组MoCA总评分较OSAHS中度组更低,差异均有统计学意义(P<0.05)。较鼾症组,OSAHS中度组、OSAHS重度组定向、延迟回忆、注意力、命名、视空间与执行评分均更低,差异均有统计学意义(P<0.05);较OSAHS中度组,OSAHS重度组延迟回忆、注意力、视空间与执行评分均更低,差异均有统计学意义(P<0.05)。(3)较鼾症组[(27.53±1.49)分],OSAHS中度组、重度组MoCA总评分[(26.32±1.37)、(24.42±1.26)分]更低,且OSAHS重度组MoCA总评分较OSAHS中度组更低,差异均有统计学意义(P<0.05)。较鼾症组,OSAHS中度组、OSAHS重度组定向、延迟回忆、注意力、命名、视空间与执行评分均更低,差异均有统计学意义(P<0.05);较OSAHS中度组,OSAHS重度组延迟回忆、注意力、视空间与执行评分均更低,差异均有统计学意义(P<0.05)。(4)中重�Objective To study the changes in the levels of serum neuropeptide Y(NPY),human growth hormone releasing peptide-Ghrelin(GHRP-Ghrelin)in patients with moderate to severe obstructive sleep apnea hypopnea syndrome(OSAHS)and their correlation with cognitive function.Methods A total of 80 OSAHS patients admitted to Suqian Hospital of Nanjing Gulou Hospital Group from January 2023 to January 2024 were retrospectively selected and the disease severity were divided into the OSAHS moderate group(n=20)and the OSAHS severe group(n=60);80 patients with simple snoring diagnosed in the same period were selected as the snoring group.Compared serum NPY and GHRP-Ghrelin levels with the mini-mental state examination(MMSE)and montreal cognitive assessment(MoCA)scores,and analyzed the correlation between NPY,GHRP-Ghrelin levels and cognitive function in patients with moderate to severe OSAHS.Results(1)Compared with the snoring group[(474.07±66.34),(1019.39±151.34)ng/L],the NPY levels in the moderate and severe OSAHS groups[(542.07±45.48),(580.14±48.63)ng/L]were higher,and the GHRP-Ghrelin levels in the moderate and severe OSAHS groups[(800.02±135.47),(736.24±147.65)ng/L]were lower,the differences were statistically significant(P<0.05).Compared with the moderate OSAHS group,the NPY level in the severe OSAHS group was higher,and the GHRP-Ghrelin level in the severe OSAHS group was lower,the difference was statistically significant(P<0.05).(2)Compared with the snoring group[(28.24±0.98)points],the total MoCA scores of the OSAHS moderate group and the severe group[(27.96±0.79),(26.81±0.67)points]were lower,and the MoCA score of the OSAHS severe group was lower than that of the OSAHS moderate group,the differences were statistically significant(P<0.05).Compared with the snoring group,the orientation,delayed recall,attention,naming,visual space and execution scores of the moderate OSAHS group and the severe OSAHS group were lower,and the differences were statistically significant(P<0.05).Compared with the moderate OSAHS group,th

关 键 词：中重度阻塞性睡眠呼吸暂停低通气综合征 神经肽Y 人生长激素释放多肽 认知功能 相关性 

分 类 号：R766[医药卫生—耳鼻咽喉科]