从“骨玄府-肾藏象”探析骨免疫微环境与间充质干细胞对强直性脊柱炎异位骨化的影响  

The Effect of Bone Immune Microenvironment and Bone Mesenchymal Stem Cells on the Heterotopic Ossification of Ankylosing Spondylitis Based on the Theory of "Bone Sweat Pore-Kidney Visceral Manifestation"

作　　者：陈悦宁 刘宏潇[1] CHEN Yuening;LIU Hongxiao(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing,100053)

机构地区：[1]中国中医科学院广安门医院,北京市100053

出　　处：《中医杂志》2025年第2期128-132,共5页Journal of Traditional Chinese Medicine

基　　金：北京市中医药科技发展资金(BJZYZD-2023-02);中国中医科学院科技创新工程重点协同攻关项目(CI2023C072YLL);中国中医科学院拔尖创新博士研究生支持计划;中央高水平中医医院临床研究和成果转化能力提升项目(HLCMHPP2023049)。

摘　　要：异位骨化是强直性脊柱炎(AS)致残的重要病理环节。骨免疫微环境失衡是AS异位骨化的始动因素,骨髓间充质干细胞(BMSCs)异常成骨潜能激化是异位骨化核心环节。从中医学“骨玄府-肾藏象”的角度,认为“肾藏象”功能失调是骨免疫微环境失衡和BMSCs诱发异位骨化的基础,“骨玄府”是骨免疫微环境失衡和BMSCs诱发异位骨化的重要场所。据此提出荣肾养玄以重塑骨免疫微环境和BMSCs功能,行滞通玄以消除导致AS异位骨化的病理因素,为AS中医药治疗提供思路。Heterotopic ossification is an important pathological link leading to disability in ankylosing spondylitis(AS).Imbalance of bone immune microenvironment is the initiating factor for heterotopic ossification in AS,while abnormal osteogenic potential of bone marrow mesenchymal stem cells(BMSCs)is the core link.From the perspective of"bone sweat pore-kidney visceral manifestation"in traditional Chinese medicine,it is believed that dysfunction of"kidney visceral manifestation"is the basis for the induction of heterotopic ossification by bone immune microenvironment and BMSCs,and"bone sweat pore"is their important setting.Accordingly,it is proposed that the kidney and sweat pore should be nourished and regulated to reshape the bone immune microenvironment and BMSCs function,and that obstruction should be removed and the marrow should be unblocked to eliminate the pathological factors that lead to AS heterotopic ossification.This provides a new perspective and basis for the treatment of AS with traditional Chinese medicine.

关 键 词：强直性脊柱炎 骨玄府 肾藏象 骨免疫微环境 间充质干细胞 异位骨化 

分 类 号：R71[医药卫生—妇产科学]