基于“络脉伏风”探讨肿瘤血管生成的病机与治疗策略  

Pathogenesis and Treatment Strategies of Tumor Angiogenesis Based on the Theory "Latent Wind in Collaterals"

作　　者：普振清 王桂彬 张辰阳 李奕 庞博[2] 花宝金[2] PU Zhenqing;WANG Guibin;ZHANG Chenyang;LI Yi;PANG Bo;HUA Baojin(Beijing University of Chinese Medicine,Beijing,100029;Guang'anmen Hospital,China Academy of Chinese Medical Sciences;Guangdong Provincial Hospital of Traditional Chinese Medicine)

机构地区：[1]北京中医药大学,北京市100029 [2]中国中医科学院广安门医院 [3]广东省中医院

出　　处：《中医杂志》2025年第2期139-144,共6页Journal of Traditional Chinese Medicine

基　　金：中央高水平中医医院临床研究和成果转化能力提升项目(HLCMHPP2023005);首都卫生发展科研专项(首发2022-2-4155);中国中医科学院科技创新工程(CI2021A01805,CI2021B009)。

摘　　要：将“伏风”的致病特点与络病理论相结合,重新认识肿瘤血管大量增殖、通透性强、促进转移的病理特征,提出“络脉伏风”致癌的病机框架,即癌肿病灶处络脉禀伏风生发之性而亢变增生、禀开泄之性而渗漏精微,癌毒禀其善行数变之性而走窜传舍的恶性肿瘤演进过程。围绕“络脉伏风”的基本病机,提出临证以治风为核心的调气祛风、清热熄风、通络搜风、扶正宁风的具体治则治法,为提升恶性肿瘤中医精准化治疗水平提供参考。This article combined the pathogenic characteristics of"latent wind"with the theory of collateral diseases to clarify the pathological features of tumor blood vessels,including their active proliferation,high permeabi-lity,and promotion of metastasis.The theory framework of"latent wind in collaterals"as the tumor mechanism was proposed,which suggests that at the site of tumor lesions,the collaterals inherit the nature of latent wind to grow excessively,adopt an open and discharge nature to leak essence,and tumor toxins,characterized by their rapid movement and frequent changes,spread and metastasize,driving the progression of malignant tumors.Focusing on the fundamental pathogenesis of"latent wind in collaterals",specific clinical treatment principles and methods centered on treating wind are proposed,including regulating qi and dispelling wind,clearing heat and extinguishing wind,unblocking collaterals and expelling wind,and reinforcing healthy qi to calm wind,so as to provide references for enhancing the precision of traditional Chinese medicine in treating malignant tumors.

关 键 词：肿瘤 血管生成 伏风 络脉 络病 

分 类 号：R73[医药卫生—肿瘤]