Roles of serum uric acid on the association between arsenic exposure and incident metabolic syndrome in an older Chinese population  

作　　者：Haiyan Jiang Simei Zhang Yaoyao Lin Lin Meng Jiayi Li Wenqing Wang Kaixuan Yang Mingjuan Jin Jianbing Wang Mengling Tang Kun Chen 

机构地区：[1]Department of Public Health,Fourth Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China [2]Department of Public Health,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China [3]Department of Public Health,National Clinical Research Center for Child Health of Children’s Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China

出　　处：《Journal of Environmental Sciences》2025年第1期332-341,共10页环境科学学报(英文版)

基　　金：supported by the Fundamental Research Funds for the Central Universities(Nos.2021FZZX001-39 and 2020QNA7018);the Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province(No.20220204);the Medical Science and Technology Project of Zhejiang Province(No.2023RC037).

摘　　要：Growing evidences showed that heavy metals exposure may be associated with metabolic diseases.Nevertheless,themechanism underlying arsenic(As)exposure and metabolic syndrome(MetS)risk has not been fully elucidated.So we aimed to prospectively investigate the role of serum uric acid(SUA)on the association between blood As exposure and incident MetS.A sample of 1045 older participants in a community in China was analyzed.We determined As at baseline and SUA concentration at follow-up in the Yiwu Elderly Cohort.MetS events were defined according to the criteria of the International Diabetes Federation(IDF).Generalized linear model with log-binominal regression model was applied to estimate the association of As with incident MetS.To investigate the role of SUA in the association between As andMetS,amediation analysiswas conducted.In the fully adjusted log-binominal model,per interquartile range increment of As,the risk of MetS increased 1.25-fold.Compared with the lowest quartile of As,the adjusted relative risk(RR)of MetS in the highest quartile was 1.42(95%confidence interval,CI:1.03,2.00).Additionally,blood As was positively associated with SUA,while SUA had significant association with MetS risk.Further mediation analysis demonstrated that the association of As and MetS risk was mediated by SUA,with the proportion of 15.7%.Our study found higher As was remarkably associated with the elevated risk of MetS in the Chinese older adults population.Mediation analysis indicated that SUA might be a mediator in the association between As exposure and MetS.

关 键 词：Arsenic(As)exposure Metabolic syndrome(MetS) Serum uric acid(SUA) Cohort study Mediation effect Older adults 

分 类 号：R58[医药卫生—内分泌]