Arsenic exposure and oxidative damage to lipid,DNA,and protein among general Chinese adults:A repeated-measures cross-sectional and longitudinal study  

作　　者：Yongfang Zhang Min Zhou Dongming Wang Ruyi Liang Wei Liu Bin Wang Weihong Chen 

机构地区：[1]Department of Occupational and Environmental Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Key Laboratory of Environment and Health,Ministry of Education and Ministry of Environmental Protection,and State Key Laboratory of Environmental Health(Incubating),School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

出　　处：《Journal of Environmental Sciences》2025年第1期382-391,共10页环境科学学报(英文版)

基　　金：supported by the National Natural Science Foundation of China(Nos.82241088 and 82203996);the China Postdoctoral Science Foundation(Nos.2022T150230 and 2021M691131).

摘　　要：Arsenic-related oxidative stress and resultant diseases have attracted global concern,while longitudinal studies are scarce.To assess the relationship between arsenic exposure and systemic oxidative damage,we performed two repeatedmeasures among 5236 observations(4067 participants)in theWuhan-Zhuhai cohort at the baseline and follow-up after 3 years.Urinary total arsenic,biomarkers of DNA oxidative damage(8-hydroxy-2-deoxyguanosine(8-OHdG)),lipid peroxidation(8-isoprostaglandin F2alpha(8-isoPGF2α)),and protein oxidative damage(protein carbonyls(PCO))were detected for all observations.Here we used linearmixed models to estimate the cross-sectional and longitudinal associations between arsenic exposure and oxidative damage.Exposure-response curves were constructed by utilizing the generalized additive mixed models with thin plate regressions.After adjusting for potential confounders,arsenic level was significantly and positively related to the levels of global oxidative damage and their annual increased rates in dose-response manners.In cross-sectional analyses,each 1%increase in arsenic levelwas associated with a 0.406%(95%confidence interval(CI):0.379%to 0.433%),0.360%(0.301%to 0.420%),and 0.079%(0.055%to 0.103%)increase in 8-isoPGF2α,8-OHdG,and PCO,respectively.More importantly,arsenic was further found to be associated with increased annual change rates of 8-isoPGF2α(β:0.147;95%CI:0.130 to 0.164),8-OHdG(0.155;0.118 to 0.192),and PCO(0.050;0.035 to 0.064)in the longitudinal analyses.Our study suggested that arsenic exposurewas not only positively related with global oxidative damage to lipid,DNA,and protein in cross-sectional analyses,but also associated with annual increased rates of these biomarkers in dose-dependent manners.

关 键 词：Arsenic Oxidative stress Oxidative damage 8-isoPGF2α 8-OHDG Protein carbonyls(PCO) 

分 类 号：P59[天文地球—地球化学]