芳香化酶抑制剂在改善儿童身材矮小症中的作用  

Improve effects of aromatase inhibitors on the height of children with short stature

作　　者：夏萌萌 向金波 罗军[1] 朱晓霞[1] XIA Mengmeng;XIANG Jinbo;LUO Jun;ZHU Xiaoxia(Dept.of Pediatrics,Renhe Hospital Affiliated to Three Gorges University,Hubei Yichang 443001,China;Dept.of Neonatology,Renhe Hospital Affiliated to Three Gorges University,Hubei Yichang 443001,China)

机构地区：[1]三峡大学附属仁和医院儿科,湖北宜昌443001 [2]三峡大学附属仁和医院新生儿科,湖北宜昌443001

出　　处：《中国药房》2025年第4期501-506,共6页China Pharmacy

基　　金：湖北省教育厅科学研究计划项目(No.Q20211203);肿瘤微环境与免疫治疗湖北省重点实验室(三峡大学)开放基金课题(No.2022KZL2-09);宜昌市医疗卫生研究项目(No.A24-2-044)。

摘　　要：临床治疗儿童身材矮小症(SS)的主要方法是使用重组人生长激素(rhGH),但其高昂的治疗费用以及每日1次的注射频率,给患儿家庭带来了沉重的经济和精神负担,对于已经错过青春期生长峰速期的SS青少年,单独使用rhGH也难以显著提高其成人终身高。众多研究表明,芳香化酶抑制剂(AIs)在改善SS男童身高方面有效,尤其是AIs与rhGH联合疗法,效果更优。虽然使用AIs后会对患儿骨骼、精神认知、生殖系统及激素水平产生影响,但大多是暂时的。由于现有研究未完全明确其对SS女童青春期变化的影响,临床在使用AIs治疗SS女童时,需要充分权衡获益和风险。未来还需要开展基于我国医疗环境的药物经济学研究,以评价AIs用于儿童SS的经济性。The primary approach for clinical treatment of short stature(SS)in children is the use of recombinant human growth hormone(rhGH).However,the high cost of treatment and the daily injection frequency place a significant economic and psychological burden on the families of affected children.For SS adolescents who have missed the peak growth velocity period of puberty,the use of rhGH alone is also difficult to significantly increase their final adult height.Numerous studies have shown that aromatase inhibitors(AIs)are effective in improving the height of SS boys,especially the combination therapy of AIs and rhGH,which has a better effect.Although the use of AIs may affect the children’s bones,cognitive function,reproductive system and hormone levels,most of these effects are temporary.Since existing research has not fully elucidated its impact on the pubertal changes of girls,it is necessary to fully weigh the benefits and risks when using AIs to treat SS girls in clinical practice.In the future,it is also necessary to carry out pharmacoeconomic research based on the medical environment of China to evaluate the costeffectiveness of AIs for SS in children.

关 键 词：芳香化酶抑制剂 身材矮小症 成人终身高 来曲唑 阿那曲唑 有效性 安全性 

分 类 号：R985[医药卫生—药品] R725.8[医药卫生—药学]