外泌体与疱疹病毒感染介导疼痛发生的研究进展  

Research progress of exosomes and herpes virus infection-mediated pain

作　　者：李陈广 高翔宇 白雨婷 许晨亮 樊碧发[3] 肖礼祖[1,2] LI Chen-guang;GAO Xiang-yu;BAI Yu-ting;XU Chen-liang;FAN Bi-fa;XIAO Li-zu(Department of Pain Medicine,Shenzhen Nanshan People's Hospital,Shenzhen 518052,China;School of Medicine,Shenzhen University,Shenzhen 518060,China;Department of Pain Medicine,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]深圳市南山区人民医院疼痛科,深圳518052 [2]深圳大学医学部,深圳518060 [3]中日友好医院疼痛科,北京100029

出　　处：《中国疼痛医学杂志》2025年第2期85-92,共8页Chinese Journal of Pain Medicine

基　　金：国家重点研发计划子课题(2022YFC3602202);国家自然科学青年基金项目(82404670);深圳南山区科技重大优秀青年项目(NSZD2024035)。

摘　　要：外泌体是一类由多种细胞分泌的磷脂双分子层包裹的囊状结构,内含多种蛋白质、脂类和核酸等。外泌体不仅参与正常的免疫调节和细胞间的信息传递,还参与各种疾病的发生和发展。单纯疱疹病毒和水痘-带状疱疹病毒属于人类α疱疹病毒,感染后可引发皮肤病变和神经病理性疼痛等症状。本文将重点综述外泌体在疱疹病毒感染过程及其相关疾病中的作用,特别是在病毒感染和带状疱疹后神经痛方面的机制研究。疱疹病毒感染中的外泌体有望成为疱疹性相关疾病预防、诊断和治疗的新策略。Exosomes are sac-like structures encapsulated by a lipid bilayer secreted by various cell types,containing diverse proteins,lipids,DNA and nucleic acid.Exosomes are not only involved in normal physiological processes,immune regulation and intercellular information transmission,but also involved in the occurrence and development of various diseases.Herpes simplex virus and varicella-zoster virus,members of the humanαherpes viruses,are known to cause skin lesions and neuropathic pain after infection.This review focuses on the role of exosomes in the process of herpes virus infection and related diseases,in particular in the mechanism of viral infection and neuropathic pain after herpes zoster.Exosomes in herpesvirus infection may become a new strategy for preventing,diagnosing,and treating herpes-related diseases.

关 键 词：外泌体 疱疹病毒 单纯疱疹病毒 水痘-带状疱疹病毒 疼痛 

分 类 号：R402[医药卫生—临床医学]