脊柱关节退变外泌体与自噬串扰的研究进展  

Advances in the study of exosomes and autophagy crosstalk in spine and joint degenerations

作　　者：闫炳翰 仇道迪 徐展望[2] 谭国庆[2] YAN Bing-han;QIU Dao-di;XU Zhan-wang;TAN Guo-qing(Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Affiliated Hospital,Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]山东中医药大学附属医院,山东济南250014

出　　处：《中国矫形外科杂志》2025年第1期64-69,共6页Orthopedic Journal of China

基　　金：国家自然科学基金面上项目(编号:82174410);山东省自然科学基金项目(编号:ZR2020KH011);山东省自然科学基金面上项目(编号:ZR2020MH362);全国名老中医药专家传承工作室建设项目(编号:国中医药人教函[2022]75号)。

摘　　要：椎间盘退变(intervertebral disc degeneration,IDD)和骨关节炎(osteoarthritis,OA)是临床常见的脊柱关节退行性疾病,严重影响患者的生活质量,目前尚无有效的根治方法。不同来源的外泌体与自噬的串扰能够延缓IDD和OA的进展,其作用机制涉及抑制相关细胞凋亡和保护细胞外基质等。本文通过归纳近年来相关文献,综述了外泌体与自噬的串扰在脊柱关节退行性疾病诊疗中的应用现状,发现自噬是治疗脊柱关节退行性疾病的新兴靶点,外泌体中包含骨重建所需的多种生物活性物质,二者的相互串扰可进一步提高IDD和OA的疗效,以期为今后该领域的研究提供参考。Intervertebral disc degeneration(IDD)and osteoarthritis(OA)are common spine and joint degenerative diseases,which seri-ously affect people's quality of life.Currently,there is no effective radical treatment.The crosstalk between exosomes and autophagy of differ-ent origin can delay the progression of IDD and OA,and its mechanism involves inhibiting apoptosis and protecting extracellular matrix.Byreviewing relevant literature in recent years,this paper described the application status of exosomes and autophagy in the diagnosis and treat-ment of spinal and articular degenerative diseases,and found that autophagy might be an emerging target for the treatment of osteoarticulardegenerative diseases.Exosomes contain a variety of bioactive substances required for bone reconstruction,and the mutual interference ofthe two can further improve the efficacy of IDD and OA.It is expected to provide reference for future research in this field.

关 键 词：椎间盘退变 骨关节炎 外泌体 自噬 

分 类 号：R684.3[医药卫生—骨科学]