骨髓脂肪对定量CT骨密度测量值影响的动物实验研究  

Effect of bone marrow fat on quantitative CT bone mineral density measurements:an animal study

作　　者：黄子奉 李春燕[2] 许洲莹[3] 符维艳 曾凡萍 HUANG Zi-feng;LI Chun-yan;XU Zhou-ying(The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Guangxi 530000,China)

机构地区：[1]广西中医药大学第一附属医院,530000 [2]广西医科大学第一附属医院,530000 [3]广西医科大学附属肿瘤医院,530000

出　　处：《放射学实践》2025年第2期260-264,共5页Radiologic Practice

摘　　要：目的:采用放射疗法构建巴马小型猪腰椎骨髓脂肪化模型,观察骨髓脂肪变化对椎体定量CT(QCT)骨密度(BMD)测量值的影响。方法:20头巴马小型猪随机分为实验组12头,验证组4头,正常组4头。实验组、验证组均采用放射疗法构建腰椎骨髓脂肪化模型,正常组不予干预。建模前一天与建模后第14天,所有动物行腰椎QCT和MRI IDEAL-IQ序列扫描,测量各椎体松质骨的QCT BMD值(BMD_(QCT))和骨髓脂肪分数(BMFF)。最后采用电感耦合等离子体发射光谱法(ICP-AES)测定椎体钙含量(VCC)。结果:建模后,与正常组比较,实验组、验证组腰椎BMFF明显增高,BMD_(QCT)值显著降低,差异有统计学意义(P<0.05);各组腰椎VCC值差异无统计学意义(P>0.05);实验组建模前、后腰椎BMD_(QCT)差值(建模后BMD_(QCT)-建模前BMD_(QCT))与BMFF差值(建模后BMFF-建模前BMFF)之间存在显著负相关关系,r=-0.677,回归方程:Y=-0.921X-2.820,P<0.001,调整R^(2)=0.448,Y代表BMD_(QCT)差值,X代表BMFF差值。即腰椎BMFF每增加1%,BMD_(QCT)则减少0.921 mg/cm^(3);利用回归方程计算验证组腰椎BMD_(QCT)(校正),与正常组BMD_(QCT)比较,差异无统计学意义(P>0.05)。结论:骨髓脂肪影响QCT BMD测量的准确性,在椎体实际骨矿物质含量不变的情况下,椎体骨髓脂肪含量越高,QCT BMD值越低,两者存在显著负相关关系。运用QCT进行骨质疏松症诊断时需校正骨髓脂肪的影响,以提高骨质疏松风险评估及骨折预测的准确性。Objective:To observe the effect of bone marrow fat changes on bone mineral density(BMD)measured by quantitative computed tomography(QCT)in the lumbar spine of Bama miniature pigs by using radiotherapy to construct a model of bone marrow fat.Methods:Twenty bama miniature pigs were randomly divided into an experimental group(n=12),a validation group(n=4)and a normal group(n=4).The experimental group and the verification group were treated with radiotherapy to construct a lumbar bone marrow fat model.The normal group was not intervened.On the day before modeling and the 14th day after modeling,all animals underwent lumbar QCT and MRI IDEAL-IQ sequence scans to measure the QCT BMD value(BMD_(QCT))and bone marrow fat fraction(BMFF)of each vertebral cancellous bone.Finally,vertebral calcium content(VCC)was determined by inductively coupled plasma atomic emission spectrometry(ICP-AES).Results:After modeling,compared with the normal group,the BMFF of the lumbar spine in the experimental group and the verification group was significantly increased,and the BMD_(QCT) value was significantly decreased,the difference was statistically significant(P<0.05).There was no significant difference in the VCC value of the lumbar spine in each group(P>0.05).In the experimental group,there was a significant negative correlation between the difference of lumbar BMD_(QCT)(BMD_(QCT) after modeling-BMD_(QCT) before modeling)and the difference of BMFF(BMFFafter modeling-BMFFbefore modeling),r=-0.677,the regression equation was:Y=-0.921X-2.820,P<0.001,adjusted R^(2)=0.448,Y represents the difference of BMD_(QCT),X represents the difference of BMFF.BMD_(QCT) decreased by 0.921mg/cm^(3) for every 1%increase in lumbar BMFF.The regression equation was used to calculate the BMD_(QCT)(correction)of the lumbar spine in the validation group,and there was no significant difference between the validation group and the normal group(P>0.05).Conclusion:Bone marrow fat influences the accuracy of QCT BMD measurement.When the actual bone mineral content of t

关 键 词：体层摄影术 X线计算机 骨密度 骨质疏松 骨髓 

分 类 号：R814.4[医药卫生—影像医学与核医学] R336[医药卫生—放射医学] R681[医药卫生—临床医学] R322.2