在轨失眠相关机制的研究现状与中药干预策略展望  

Research Status of On-orbit Insomnia Related Mechanisms and Prospects of Chinese Medicine Intervention Strategy

作　　者：崔德蓉 郭海燕[2] 张海力 尹鹤錞 郭奕廷 CUI Derong;GUO Haiyan;ZHANG Haili;YIN Hechun;GUO Yiting(Institute of Basic Theory of Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Graduate School,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Clinical Basic Theory of Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Beijing University of Chinese Medicine,Beijing 100105,China;Shanghai University of Traditional Chinese Medicine,Shanghai 200120,China)

机构地区：[1]中国中医科学院中医基础理论研究所,北京100700 [2]中国中医科学院研究生院,北京100700 [3]中国中医科学院中医临床基础理论研究所,北京100700 [4]北京中医药大学,北京100105 [5]上海中医药大学,上海200120

出　　处：《载人航天》2025年第1期67-74,共8页Manned Spaceflight

基　　金：航天医学基础与应用国家重点实验室开放课题(SMFA20K30)。

摘　　要：失眠是在轨环境中航天员最常见的问题之一,睡眠不足不仅影响航天员自身的健康,还可引起航天员认知及操作绩效下降。目前,在轨失眠的治疗主要采用苯二氮卓类药物,但长期用药存在药物耐受、成瘾等副作用,而中药治疗地面失眠表现出较好的疗效且安全性高。针对上述问题,通过综述国内外现有在轨失眠的机制与中药治疗地面失眠的研究,探讨中药干预在轨失眠的可能性。已有研究表明,部分治疗地面失眠的中药单药或复方可能通过调节生物节律、睡眠相关激素水平进而对改善在轨失眠有效。Insomnia is one of the most common problems of astronauts in the on-orbit environment.Insufficient sleep not only affects the health of astronauts themselves,but also causes the decline of astronauts’cognitive and operational performance.At present,benzodiazepines are mainly used in the treatment of on-orbit insomnia,but long-term medication has obvious side effects such as drug tolerance and addiction.Chinese medicine treatment of ground insomnia showed good efficacy and high safety.In order to provide new ideas for the treatment of on-orbit insomnia,the existing mecha-nisms of on-orbit insomnia and the specific mechanisms related to the treatment of terrestrial insom-nia by traditional Chinese medicine(TCM)were reviewed,and the possibility of TCM intervening on-orbit insomnia was explored.Studies showed that some TCM monotherapy or combination formu-las for the treatment of terrestrial insomnia may be effective for the on-orbit insomnia by regulating biological rhythms and sleep-related hormone levels.

关 键 词：航天员 在轨失眠 生物节律 生物钟基因 激素 中药 

分 类 号：V7[航空宇航科学技术]