Role of per-and polyfluoroalkyl substances in the cardiorenal system:Unraveling crosstalk from the network of pollutants and phenotypes  

作　　者：Ming Yang Jiaxin Zhao Ziwen An Haoran Li Chaoying Ma Junli Lv Fang Xiao Zhenzhen Tan Longfei Li Xiaoguang Zhang Xuehui Liu Yi Liu Ang Li Huicai Guo 

机构地区：[1]Department of Epidemiology and Biostatistics,Institute of Basic Medical Sciences Chinese Academy of Medical Sciences,School of Basic Medicine Peking Union Medical College,Beijing 100005,China [2]Center of Environmental and Health Sciences,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100005,China [3]Department of Toxicology,School of Public Health,Hebei Medical University,Shijiazhuang 050017,China [4]Hebei Key Laboratory of Environment and Human Health,Hebei Province,Shijiazhuang 050017,China [5]Department of Pharmacy,The Second Hospital of Hebei Medical University,Shijiazhuang 050000,China [6]Core Facilities and Centers of Hebei Medical University,Shijiazhuang 050017,China [7]The Key Laboratory of Neural and Vascular Biology,Ministry of Education,Shijiazhuang 050017,China

出　　处：《Journal of Environmental Sciences》2025年第4期116-133,共18页环境科学学报(英文版)

基　　金：supported by the China Postdoctoral Science Foundation(Nos.2023M730317 and 2023T160066);the Fundamental Research Funds for the Central Universities(No.3332023042);the Open Project of Hebei Key Laboratory of Environment and Human Health(No.202301);the Programs of the National Natural Science Foundation of China(No.21976050);the Science and Technology Program of Hebei Province(No.21377779D);the Natural Science Foundation of Hebei Province,China(No.B2020206008).

摘　　要：Although per-and polyfluoroalkyl substances(PFAS)have been frequently linked to cardiovascular and renal disease separately,evidence remains scarce regarding their systematic effect.Therefore,we recruited 546 newly diagnosed acute coronary syndrome(ACS)patients and detected seven myocardial enzymes and six kidney function biomarkers.Twelve PFASwere also assessedwith ultra-high-performance liquid chromatography-tandem mass spectrometry.Generalized linear model and restricted cubic spline model were applied to single pollutant analysis.Quantile g-computation was used for mixture analysis.Network model was utilized to identify central and bridge nodes of pollutants and phenotypes.In the present study,perfluorohexane sulfonic acid was positively associated with uric acid(UA)(β=0.04,95%confidence interval(CI):0.01,0.07),and perfluorobutanoic acid was negatively associated with estimated glomerular filtration rate(β=-0.04,95%CI:-0.07,-0.01)but positively associated with UA(β=0.03,95%CI:0.01,0.06).In mixture analysis,each quantile increase in the PFAS mixture was significantly associated with UA(β=0.08,95%CI:0.04,0.11).Network analysis revealed that perfluorooctanoate,UA,and myoglobin were denoted as bridge nodes,and the first principal component of lactate dehydrogenase and creatine kinase-myocardial band was identified as the node with the highest strength and expected influence.This study investigates the systematic impact of PFAS exposure through cardiorenal interaction network,which highlights that PFAS may serve as an upstream approach in UA-modulated cardiorenal network to affect cardiorenal system comprehensively.

关 键 词：Per-and polyfluoroalkyl substances Cardiorenal system Network analysis Acute coronary syndrome 

分 类 号：X592[环境科学与工程—环境工程]