血清CC-16、sST2、FGF2水平与急性呼吸窘迫综合征预后的关系  

Relationship between serum levels of CC-16, sST2 and FGF2 and prognosis of acute respiratory distress syndrome

作　　者：李燕 桑艳霞 闫晓笑 刘桢干 郭海伟 LI Yan;SANG Yan-xia;YAN Xiao-xiao(Department of Critical Care Medicine,General Hospital of Taiyuan Steel(Group)Co.,Ltd.(The Sixth Affiliated Hospital of Shanxi Medical University),Taiyuan Shanxi 030007,China;Department of Surgery Teaching and Research Office,Shanxi Technology and Business University,Taiyuan Shanxi 030036,China)

机构地区：[1]太原钢铁(集团)有限公司总医院(山西医科大学附属第六医院)重症医学科,山西太原030007 [2]山西工商学院外科教研室,山西太原030036 [3]山西中医药大学附属医院重症医学科,山西太原030024

出　　处：《临床和实验医学杂志》2025年第1期18-21,共4页Journal of Clinical and Experimental Medicine

基　　金：山西省卫生健康委科研课题(编号:2019183)。

摘　　要：目的 研究血清Clara细胞分泌蛋白-16(CC-16)、可溶性基质裂解素2(sST2)、碱性成纤维细胞生长因子2(FGF2)水平与急性呼吸窘迫综合征(ARDS)预后的关系。方法 回顾性选取2023年2月至2024年2月在太原钢铁(集团)有限公司总医院(山西医科大学附属第六医院)收治的92例ARDS患者进行试验,根据患者28 d后的预后情况分为存活组69例及死亡组23例。比较两组患者相关基线资料,检测两组患者血清CC-16、sST2、FGF2水平;采用多因素Logistic回归分析影响ARDS患者预后的危险因素;通过受试者操作特征(ROC)评估血清CC-16、sST2、FGF2水平预测ARDS患者预后的价值。结果 两组基线资料比较,差异均无统计学意义(P>0.05),存活组血清CC-16、sST2、FGF2水平分别为(60.41±10.32) ng/L、(1 015.14±246.85) pg/mL、(24.32±3.39) pg/mL,均低于死亡组[(85.74±10.36) ng/L、(1 265.47±256.14) pg/mL、(31.26±4.55) pg/mL],差异均有统计学意义(P<0.05)。经多因素回归分析,血清CC-16、sST2、FGF2均是影响ARDS患者预后的危险因素(P<0.05)。经过ROC曲线分析证实,血清CC-16、sST2、FGF2均可用于ARDS患者预后的预测,曲线下面积分别为0.982、0.819、0.916(P<0.05)。结论 血清CC-16、sST2和FGF2的的含量呈现出明显的升高趋势,可作为评估ARDS患者预后的重要参考指标,有助于医师制定更加精准的治疗方案。Objective To study the relationship between serum Clara cell secretory protein-16(CC-16),soluble suppssion of tumorigenicity-2(sST2)and basic fibroblast growth factor-2(FGF2)and the prognosis of acute respiratory distress syndrome(ARDS).Methods A retrospective study was conducted on 92 patients with ARDS admitted to General Hospital of Taiyuan Steel(Group)Co.,Ltd.(The Sixth Affiliated Hospital of Shanxi Medical University)from February 2023 to February 2024.According to the prognosis after 28 days,the patients were divided into the survival group(69 cases)and the death group(23 cases).The baseline data of the two groups were compared,and the serum levels of CC-16,sST2 and FGF2 were detected.The risk factors affecting the prognosis of ARDS patients was analyzed using Logistic regression,and the value of levels of serum CC-16,sST2 and FGF2 in predicting the prognosis of ARDS patients was evaluated using receiver operating characteristic(ROC).Results There were no significant differences in baseline data between the two groups(P>0.05).The serum levels of CC-16,sST2 and FGF2 in the survival group were(60.41±10.32)ng/L,(1015.14±246.85)pg/mL and(24.32±3.39)pg/mL,respectively,which were lower than those in the death group[(85.74±10.36)ng/L,(1265.47±256.14)pg/mL,(31.26±4.55)pg/mL],the differences were statistically significant(P<0.05).Multivariate regression analysis showed that serum CC-16,sST2 and FGF2 were all risk factors for the prognosis of ARDS patients(P<0.05).ROC analysis confirmed that serum CC-16,sST2 and FGF2 could be used to predict the prognosis of ARDS patients,and the areas under the curve were 0.982,0.819 and 0.916,respectively(P<0.05).Conclusion The contents of serum CC-16,sST2 and FGF2 show an obvious upward trend,which can be used as an important reference index to evaluate the prognosis of ARDS patients and help doctors to make more accurate treatment plans.

关 键 词：Clara细胞分泌蛋白-16 可溶性基质裂解素2 碱性成纤维细胞生长因子2 急性呼吸窘迫综合征 预后 

分 类 号：R563.8[医药卫生—呼吸系统]