北京市多地区汉族绝经后妇女骨质疏松症患病率研究  

Study on the prevalence of postmenopausal osteoporosis of Han nationality in Beijing

作　　者：易祖玲[1] 安宁 林吉生[1] 李嘉仪 范子寒 费琦[1] YI Zu-ling;AN Ning;LIN Ji-sheng(Department of Orthopedics,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China.;Department of Ultrasound,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院骨科,北京100050 [2]首都医科大学附属北京友谊医院超声科,北京100050

出　　处：《临床和实验医学杂志》2025年第1期62-65,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的调查北京多地区汉族绝经后妇女骨质疏松症(PMOP)不同诊断标准下的患病率情况,并探讨PMOP的临床危险因素以及患病率随年龄的变化趋势。方法采用横断面研究,抽取自2021年1月至2022年12月来自北京市的7家综合医院进行健康体检的汉族绝经后女性作为研究对象。共有672名受试者完成双能X线吸收测定法(DXA)检测骨密度,筛选出最终558受试者纳入本研究。根据不同部位骨密度t值(≤-2.5 SD)定义不同的诊断标准,包括腰椎、股骨颈、髋部总、“股骨颈+髋”和世界卫生组织(WHO)标准,计算不同标准下总体样本人群的PMOP患病率。并按不同年龄分为5组,分别为40-49岁(n=12)、50~59岁(n=165)、60~69岁(n=241)、70~79岁(n=101)、80~89岁(n=39),分析不同诊断标准下PMOP患病率随年龄的变化趋势。结果在腰椎L_(1~4)、股骨颈、髋部总、“股骨颈+髋”和WHO共计5个标准下PMOP患病率分别为26.3%(147/558)、17.9%(100/558)、11.5%(64/558)、19.7%(110/558)、34.6%(193/558)。在腰椎诊断标准下,PMOP组妇女的年龄高于非PMOP组,体重、身高及不同部位骨密度方面均高于非PMOP组,差异均有统计学意义(P<0.05)。在股骨颈、股骨颈+髋部总以及WHO诊断标准下,两组之间除上述因素外,PMOP组妇女的既往骨折史占比显著高于非PMOP组,差异有统计学意义(P<0.05)。在髋部总标准下,两组之间除上述因素外,饮酒史占比显著高于非PMOP组,差异有统计学意义(P<0.05)。结论北京市汉族PMOP不容忽视,不同诊断标准下PMOP的患病率差异较大,年龄、身高、体重、既往骨折史、饮酒史可能是PMOP的临床危险因素,且患病率具有明显的年龄相关性。Objective To investigate the prevalence of postmenopausal osteoporosis(PMOP)of Han nationality in Beijing under different diagnostic criteria,and to investigate the clinical risk factors for PMOP,as well as the changing trend of the prevalence with age and regional distribution.Methods A cross-sectional study was conducted to select Han nationality postmenopausal women who underwent physical examination from seven general hospitals in Beijing from January 2021 to December 2022.A total of 672 subjects completed dual-energy X-ray absorptiometry(DXA)to detect bone mineral density,and finally 558 subjects were included in this study.Different PMOP diagnostic criteria were defined according to the T-values of different parts(≤-2.5 SD),including the lumbar spine,femoral neck,total hip,"femoral neck+hip"and the world health organization(WHO)criteria.The prevalence of PMOP in the overall sample population under different criteria was calculated.The patients were divided into 5 groups according to different ages:40-49 years old(n=12),50-59 years old(n=165),60-69 years old(n=241),70-79 years old(n=101),80-89 years old(n=39).The trend of PMOP prevalence with age under different diagnostic criteria was analyzed.Results The prevalence of PMOP under a total of five criteria of lumbar vertebrae L_(1-4),femoral neck,total hip,"femoral neck+hip"and WHO was 26.3%(147/558),17.9%(100/558),11.5%(64/558),19.7%(110/558),34.6%(193/558)respectively.Under the diagnostic criteria of lumbar spine,the age of women in the PMOP group was higher than that in the non-PMOP group,and the body weight,height and bone mineral density in different parts were higher than those in the non-PMOP group,and the differences were statistically significant(P<0.05).Under the diagnostic criteria of femoral neck,femoral neck+hip and WHO,in addition to the above factors,the proportion of previous fracture history in PMOP group was significantly higher than that in non-PMOP group,and the differences were statistically significant(P<0.05).Under the general standar

关 键 词：骨质疏松症 绝经后妇女 患病率 骨密度 

分 类 号：R58[医药卫生—内分泌]