皮肤菌群稳态与皮肤疾病研究进展  

Skin Microbiota Homeostasisand Skin Diseases

作　　者：罗玲 王心甜 李检阅 陈彦[1,3] 刘玉萍[1,3] 邢海燕[1,2] LUO Ling;WANG Xintian;LI Jianyue;CHEN Yan;LIU Yuping;XING Haiyan(Department of Oncology,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210028,China;Department of Oncology,Jiangsu Integrated Traditional Chinese and Western Medicine Hospital,Nanjing 210028,China;Multi-Component of Traditional Chinese Medicine and Microecology Research Center,Jiangsu Provincial Academy of Chinese Medicine,Nanjing 210028,China)

机构地区：[1]南京中医药大学附属中西医结合医院肿瘤科,江苏南京210028 [2]江苏省中西医结合医院肿瘤科,江苏南京210028 [3]江苏省中医药研究院,中药组分与微生态研究中心,江苏南京210028

出　　处：《皮肤科学通报》2024年第6期680-689,共10页Dermatology Bulletin

基　　金：江苏省中医药科技发展计划重点项目(ZD202321);江苏省重点研发计划社会发展项目(BE2022816);南京中医药大学校自然基金项目(XZR2021032);南京市医疗机构中药传统制剂备案研究项目(NJCC-ZJ-202345)。

摘　　要：皮肤是人体的第一道屏障,在保护机体免受外部环境侵害的同时,也拥有免疫屏障功能。在皮肤表面定植的细菌、真菌和病毒组成了皮肤菌群,皮肤菌群、外部环境以及宿主机体三者之间形成动态的生态平衡,当这种平衡被打破时,人体就容易产生皮肤疾病。通过恢复皮肤稳态的手段进行皮肤疾病的治疗,不仅能够有效减少疾病症状,还能够降低副反应。综述了近年皮肤微生态相关的研究成果,着重关注皮肤稳态与皮肤疾病之间的关联,以及通过调整局部微生态治疗皮肤疾病的策略和途径,旨在为相关研究提供参考。The skin is the first barrier of the human body,which not only protects the body from external environmental damage,but also possesses immune barrier functions.The bacteria,fungi,and viruses that colonize the surface of the skin form a dynamic ecological balance among the skin microbiota,external environment,and host organism.When this balance is disrupted,the human body is prone to skin diseases.The treatment of skin diseases by restoring skin homeostasis can not only effectively reduce disease symptoms but also reduce side effects.This article reviews the research achievements related to skin microbiota in recent years,focusing on the relationship between skin homeostasis and skin diseases,as well as strategies and pathways for treating skin diseases by adjusting local microbiota,with the aim of providing reference for related research.

关 键 词：皮肤菌群稳态 皮肤疾病 微生态治疗 皮肤屏障 机制 

分 类 号：R751[医药卫生—皮肤病学与性病学]