CT联合血清Survivin、MIF对肺结核合并肺癌患者的临床诊断价值  

Clinical Diagnostic Value of CT Combined with Serum Survivin and Mif in Patients with Pulmonary Tuberculosis Combined with Lung Cancer

作　　者：李丹萍 寇介丽 刘娜 杨枫 刘桃桃 韩君蕊 杨立洲 Li Dan-ping;KOU Jie-li;LIU Na;YANG Feng;LIU Tao-tao;HAN Jun-rui;YANG Li-zhou(Department of CT Radiology,Cangzhou People's Hospital,Cangzhou 061000,Hebei Province,China)

机构地区：[1]沧州市人民医院CT放射科,河北沧州061000

出　　处：《中国CT和MRI杂志》2025年第2期89-91,共3页Chinese Journal of CT and MRI

基　　金：沧州市重点研发计划指导项目(222106039)。

摘　　要：目的探究CT联合凋亡抑制蛋白(Survivin)和巨噬细胞游走抑制因子(MIF)对肺结核(TB)合并肺癌患者的临床诊断价值。方法选取2020年5月至2021年6月来我院治疗的134例确诊为TB合并肺癌的患者为研究对象(合并组),另选60例同期在我院收治的TB患者为对照组。比较两组血清Survivin、MIF的水平;采用Pearson法分析血清Survivin与MIF水平的相关性;ROC曲线分析CT联合血清Survivin、MIF对TB合并肺癌患者的诊断价值。结果合并组的空泡征并发肺不张、“毛刺”征、胸膜凹陷、“分叶”征、棘状突起检出率显著高于对照组,“空洞”征检出率显著低于对照组(P<0.05),周围型“毛刺”征和“空洞”征检出率明显高于中心型,“分叶”征、空泡征并发肺不张、胸膜凹陷、棘状突起检出率明显降低(P<0.05);合并组血容量(BV)、表面通透性(PS)、平均通过时间(MTT)明显高于对照组(P<0.05);合并组血清Survivin、MIF水平显著高于对照组(P<0.05);合并组血清Survivin与MIF呈正相关(r=0.602,P=0.000);BV、PS、MTT、Survivin、MIF诊断TB合并肺癌的AUC分别为0.813、0.862、0.714、0.748、0.763,联合诊断的AUC为0.939,CT联合血清Survivin、MIF诊断TB合并肺癌优于各自单独诊断。结论TB合并肺癌患者血清Survivin、MIF水平均上调,CT联合血清Survivin、MIF对TB合并肺癌具有较高的诊断价值。Objective To explore the clinical diagnostic value of CT combined with Survivin and macrophage migration inhibitory factor(MIF)in patients with pulmonary tuberculosis(TB)combined with lung cancer.Methods From May 2020 to June 2021,134 patients diagnosed with TB combined with lung cancer who were treated in our hospital were collected as the study subjects(combination group),and another 60 tuberculosis patients were used as the reference group.Compare the levels of serum Survivor and MIF between two groups;Pearson method was applied to analyze the correlation between serum Survivin and MIF levels in patients with TB combined with lung cancer;ROC curve analysis of the diagnostic value of CT combined with serum Survivor and MIF in patients with TB and lung cancer.Results The detection rates of Vacuolar sign accompanied by atelectasis,"spiculation"sign,pleural indentation,"lobulation"sign,and spinous process in the combined group were obviously higher than those in the reference group,and the detection rate of"cavity"sign was obviously lower than that in the reference group(P<0.05),the detection rate of peripheral"spicule"sign and"cavity"sign was obviously higher than that of central type,while the detection rates of"lobulation"sign and vacuolar sign are accompanied by atelectasis,pleural depression,and spinous processes was obviously lower(P<0.05);The blood volume(BV),surface permeability(PS),and mean transit time(MTT)of the merged group were significantly higher than those of the control group(P<0.05);the serum levels of Survivin and MIF in the combined group were obviously higher than those in the reference group(P<0.05);there was a positive correlation between serum Survivin and MIF in the combined group(r=0.602,P=0.000);the AUC of BV,PS,MTT,Survivin,and MIF in diagnosing TB with lung cancer was 0.813,0.862,0.714,0.748,and 0.763,respectively,the AUC of combined diagnosis was 0.939,CT combined with serum Survivin and MIF was superior to their respective individual diagnoses in diagnosing TB with lung cancer.Conclu

关 键 词：肺结核合并肺癌 CT 凋亡抑制蛋白 巨噬细胞游走抑制因子 

分 类 号：R521[医药卫生—内科学]