FFR-CT与冠脉斑块定量参数及临床特征的相关性研究  

The Correlation between FFR-CT and Coronary Plaques Quantitative Parameters and Clinical Features

作　　者：郗艳 杨景勇[1] 邓小飞[1] 舒政[1] 杜颖 XI Yan;YANG Jing-yong;DENG Xiao-fei;SHU Zheng;DU Ying(Department of Radiology,Shanghai TCM-integrated Hospital,Shanghai 200082,China)

机构地区：[1]上海市中西医结合医院影像科,上海200082

出　　处：《中国CT和MRI杂志》2025年第2期107-109,共3页Chinese Journal of CT and MRI

基　　金：上海市虹口区卫生健康委员会医学科研课题计划(虹卫2302-06)。

摘　　要：目的定量分析冠状动脉CT的FFR-CT值和斑块的特征,收集患者的临床特征,并探讨它们之间的相关性。方法搜集2023年1月-2023年7月行CCTA检查的患者351例,通过人工智能软件计算靶血管的FFR-CT和ΔFFR,CAD-RADS评分(0-5)、斑块长度、体积、负荷(PB>0.7),最小面积(MLA<4.0mm^(2)),易损斑块,搜集患者临床相关资料,将FFR-CT<0.8定义为特异性心肌缺血组,使用SPSS分析与特异性心肌缺血和ΔFFR相关的变量。结果FFR-CT<0.8的患者共79例(79/351,22.5%)。与FFR-CT<0.8具有统计学意义的相关变量包括年龄、CAD-RADS、易损斑块、斑块负荷>0.7、MLA<4.0mm2、糖尿病以及BMI值,多参数预测FFR-CT<0.8的ROC曲线的AUC=0.99。CAD-RADS、MLA<4.0mm2以及易损斑块与ΔFFR相关。结论CAD-RADS、斑块定量参数和临床特征与FFR-CT<0.8相关。Objective Quantitatively analyze the value of CT blood flow reserve fraction(FFR-CT)and the characteristics of plaques on coronary artery CTA(CCTA)images,simultaneously the clinical characteristics of patients were collected,and the correlation between them was explored.Methods 351 Patients who underwent CCTA examination from January to July 2023 were retrospectively collected.The CCTA images of patients were imported into artificial intelligence software to calculate FFR-CT andΔFFR values of target vessels,stenosis classification CAD-RADS score(0-5),the length,volume,and load(PB>0.7)of plaque,minimum lumen area(MLA<4.0mm~2),vulnerable plaque also been evaluated.Clinical data of patients were collected,and FFR-CT<0.8 was defined as the specific myocardial ischemia group.SPSS was used to analyze variables related to FFR-CT<0.8 andΔFFR.Results There were 79 patients(79/351,22.5%)with FFR-CT<0.8.Parameters that were statistically significant with FFR-CT<0.8 included age,CAD-RADS score,vulnerable plaque,plaque load>0.7,MLA<4.0mm^(2),diabetes,and BMI.The AUC value of the ROC curve for multi-parameter prediction of FFR-CT<0.8 was 0.99.Statistically significant correlations withΔFFR included CAD-RADS scores,MLA<4.0mm~2,and vulnerable plaques.Conclusion CAD-RADS,plaque quantification parameters,and clinical features are correlated with FFR-CT<0.8.

关 键 词：冠状动脉CT动脉成像 CT血流储备分数 心肌缺血 斑块 

分 类 号：R542.2[医药卫生—心血管疾病]