儿童感染甲、乙型流感病毒血清相关细胞因子水平测定的临床意义  

Clinical Significance of Serum Cytokine Level Measurement in Children Infected with Influenza A and B Viruses

作　　者：黄良 石毅 HUANG Liang;SHI Yi(Department of Laboratory Medicine,Punan Hospital,Pudong New Area,Shanghai 200125)

机构地区：[1]上海市浦东新区浦南医院检验科,上海200125

出　　处：《医学临床研究》2025年第1期27-29,33,共4页Journal of Clinical Research

基　　金：上海市浦东新区卫健委重要薄弱学科(学科建设计划,基金号:PWZbr2022-19)。

摘　　要：【目的】探讨儿童感染甲、乙型流感病毒血清相关细胞因子水平测定的临床意义。【方法】本院收治的102例甲、乙型流感病毒感染患儿,其中感染甲型H_(1)N_(1)流感病毒患儿38例(A组),感染甲型H_(3)N_(2)流感病毒患儿34例(B组),感染乙型流感患儿30例(C组);另选40例健康儿童为对照组。根据甲、乙型流感病毒病情严重程度分为轻症组(n=78)与重症组(n=24)。比较各组血清干扰素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)、IL-10、IL-8、IL-6、IL-4和IL-2水平。【结果】与对照组比较,轻症组与重症组患儿血清中IL-6、IL-8、IL-17、TNF-α和IFN-γ水平均显著升高(P>0.05),且重症组上述指标水平明显高于轻症组(P<0.05)。三组IL-4和IL-10水平比较,差异均无统计学意义(P>0.05);重症组患儿的IL-2水平显著低于轻症组和对照组(P<0.05),轻症组IL-2水平低于对照组(P<0.05)。B组和C组的患儿血清中IL-6和TNF-α水平均高于A组(P<0.05),B组与C组的患儿血清中IL-6和TNF-α水平比较,差异无统计学意义(P>0.05);三组之间其他指标水平比较,差异均无统计学意义(P>0.05)。【结论】儿童感染甲、乙型流感病毒后,IL-6、IL-8、IL-17、TNF-α和IFN-γ的水平显著升高,尤其在重症患儿中表现更为明显,上述细胞因子可以作为评估儿童流感病情严重程度及预后的重要指标之一。【Objective】To explore the clinical significance of measuring serum cytokine levels in children infected with influenza A and B viruses.【Methods】A total of 102 children infected with influenza A and B viruses were included in this study.Among them,38 were infected with the H_(1)N_(1) strain(Group A),34 with the H_(3)N_(2) strain(Group B),and 30 with influenza B(Group C).Another 40 healthy children were selected as the control group.Based on the severity of their condition,the patients were divided into a mild group(78 cases)and a severe group(24 cases).Serum levels of interferon-γ(IFN-γ),tumor necrosis factor-alpha(TNF-α),interleukin-17(IL-17),IL-10,IL-8,IL-6,IL-4,and IL-2 were compared among the groups.【Results】Compared to the healthy control group,serum levels of IL-6,IL-8,IL-17,TNF-α,and IFN-γwere significantly elevated in both mild and severe groups(P<0.05),with the severe group showing higher levels than the mild group(P<0.05).There were no statistically significant differences in IL-4 and IL-10 levels among the three groups(P>0.05).IL-2 levels in the severe group were significantly lower than those in the mild group and the control group(P<0.05),and the mild group had lower IL-2 level than the control group(P<0.05).Serum levels of IL-6 and TNF-αin Groups B and C were higher than in Group A(P<0.05),but there was no significant difference between Groups B and C(P>0.05).No statistically significant differences were observed in the levels of other indicators among the three groups(P>0.05).【Conclusion】After infection with influenza A and B viruses,children exhibited significantly elevated levels of IL-6,IL-8,IL-17,TNF-α,and IFN-γ,especially in severe cases.Measurement of cytokine levels can serve as an important indicator for assessing the severity and prognosis of influenza in children.

关 键 词：流感病毒A型 流感病毒B型 儿童 细胞因子类 

分 类 号：R373.13[医药卫生—病原生物学]