左甲状腺素钠治疗甲状腺功能减退症患儿的疗效及对患儿甲状腺激素、anti-TG、TSHR-Ab水平的影响  

Effects of Levothyroxine Sodium on Thyroid Hormone,anti-TG and TSHR-Ab Levels in Children with Hypothyroidism

作　　者：林承杰 LIN Chengjie(Xinyang Central Hospital of Henan Province,Xinyang Henan 464000)

机构地区：[1]河南省信阳市中心医院,河南信阳464000

出　　处：《医学临床研究》2025年第1期34-36,40,共4页Journal of Clinical Research

基　　金：河南省医学科技攻关计划联合共建立项项目(LHGJ20200568)。

摘　　要：【目的】探讨左甲状腺素钠治疗甲状腺功能减退症(简称甲减)患儿的疗效及对患儿促甲状腺激素(TSH)、抗甲状腺球蛋白抗体(anti-TG)、促甲状腺激素受体抗体(TSHR-Ab)水平的影响。【方法】选取2023年4月至2024年4月本院收治的160例甲减患儿,按照抽签法随机分为对照组(采用甲状腺片治疗)和观察组(采用左甲状腺素钠治疗),每组80例,两组均连续用药6个月。比较两组临床疗效、不良反应发生情况及TSH、anti-TG、TSHR-Ab、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))水平。【结果】用药6个月后,观察组临床总有效率为95.00%,显著高于对照组的83.75%,差异有统计学意义(P<0.05)。用药6个月后,两组患儿TSH、anti-TG、TSHR-Ab水平低于用药前,FT_(3)、FT_(4)高于用药前(P<0.05);用药后6个月后,观察组TSH、anti-TG、TSHR-Ab水平均低于对照组,FT_(3)、FT_(4)水平高于对照组,差异均有统计学意义(P<0.05)。用药期间,观察组患儿不良反应总发生率明显低于对照组(P<0.05)。【结论】采用左甲状腺素钠治疗甲减患儿,能有效提高患儿临床疗效,改善TSH、anti-TG、TSHR-Ab等指标水平,且具有较好的安全性。【Objective】To investigate the efficacy of levothyroxine sodium in the treatment of children with hypothyroidism(hypothyroidism)and its influence on the levels of thyroid stimulating hormone(TSH),anti-thyroglobulin antibody(anti-TG)and thyroid stimulating hormone receptor antibody(TSHR-Ab).【Methods】A total of 160 children with hypothyroidism admitted to our hospital from April 2023 to April 2024 were randomly divided into the control group(treated with thyroid tablets)and the observation group(treated with levothyroxine sodium)according to the random drawing method,with 80 cases in each group.Both groups were given continuous medication for 6 months.The clinical efficacy,occurrence of adverse reactions and levels of TSH,anti-TG,TSHR-Ab,free triiodothyronine(FT_(3))and free thyroxine(FT_(4))were compared between the two groups.【Results】After 6 months of treatment,the total clinical effective rate of the observation group was 95.00%,which was significantly higher than that of control group(83.75%),and the difference was statistically significant(P<0.05).After 6 months of treatment,the levels of TSH,anti-TG and TSHR-Ab were lower than before treatment,while FT_(3)and FT_(4)levels were higher than before treatment(P<0.05).Six months after treatment,the levels of TSH,anti-TG and TSHR-Ab in the observation group were lower than those in control group,while FT_(3)and FT_(4)levels were higher than those in control group,with statistical significance(P<0.05).【Conclusion】The use of levothyroxine sodium in the treatment of hypothyroidism in children can effectively improve the clinical efficacy,improve the level of TSH,anti-TG,TSR-Ab and other indicators,and has a good safety.

关 键 词：甲状腺素 甲状腺功能减退症 甲状腺激素类 

分 类 号：R725.812[医药卫生—儿科]