替罗非班联合腺苷对冠心病患者PCI术后微循环、心功能的影响  

Effect of Tirofiban Combined with Adenosine on Microcirculation and Cardiac Function in Patients with Coronary Heart Disease after PCI

作　　者：李妮妮 李新国 LI Nini;LI Xinguo(Department of Cardiology,the Xianyang Hospital,Yan'an University,Xianyang Shaanxi 712000)

机构地区：[1]延安大学咸阳医院心血管内科,陕西咸阳712000

出　　处：《医学临床研究》2025年第1期71-74,共4页Journal of Clinical Research

摘　　要：【目的】探讨替罗非班联合腺苷对冠心病患者经皮冠状动脉介入治疗(PCI)术后微循环、心功能的影响。【方法】选择2020年1月至2022年5月本院收治的120例行PCI术治疗的冠心病患者,采用随机数字表法分为观察组和对照组,每组60例。对照组术前给予替罗非班,观察组术前给予替罗非班联合腺苷。比较两组手术前后血清心肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)水平,比较两组术后即刻心肌微循环指标[心肌梗死溶栓治疗(TIMI)血流分级、矫正TIMI帧数(CTFC)],比较两组手术前后心功能指标[左心室收缩末内径(LVESD)、左心室舒张末内径(LVEDD)、左室射血分数(LVEF)],比较术后两组心血管不良事件(MACE)发生率。【结果】术前,两组血清cTnI、CK-MB水平比较,差异无统计学意义(P>0.05);术后,两组血清cTnI、CK-MB水平均低于同组术前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组术后即刻TIMI血流分级比较,差异无统计学意义(P>0.05);观察组术后即刻CTFC小于对照组,差异有统计学意义(P<0.05)。两组术后LVEF高于同组术前,LVESD、LVEDD低于同组术前,差异有统计学意义(P<0.05);观察组术后LVEF高于对照组术后,LVESD、LVEDD低于对照组术后,差异有统计学意义(P<0.05)。观察组MACE发生率为1.67%(1/60),显著低于对照组的15.00%(9/60),差异有统计学意义(P<0.05)。【结论】替罗非班联合腺苷用于冠心病患者PCI术前,可有效改善患者心肌微循环,提高患者心功能。【Objective】To investigate the effects of Tirofiban combined with adenosine on microcirculation and cardiac function in patients with coronary heart disease after percutaneous coronary intervention(PCI).【Objective】A total of 120 patients with coronary heart disease who underwent PCI in our hospital from January 2020 to May 2022 were selected and divided into observation group and control group by random number table,with 60 cases in each group.The control group was given tirofiban before surgery,the observation group was given Tirofiban combined with adenosine before surgery.The serum levels of cardiac troponin I(cTnI)and creatine kinase isoenzyme(CK-MB)were compared between the two groups before and after operation.The indexes of myocardial microcirculation immediately after operation[thrombolysis in myocardial infarction(TIMI)blood flow grading and correcting TIMI frame count(CTFC)]were compared between the two groups.The indexes of cardiac function before and after operation[left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)]were compared between the two groups.The incidence of major adverse cardiovascular events(MACE)was also compared between the two groups.【Results】Before operation,there was no significant difference in serum cTnI and CK-MB levels between 2 groups(P>0.05).After operation,serum cTnI and CK-MB levels in 2 groups were lower than before operation,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).There was no significant difference in immediate TIMI blood flow classification between the two groups(P>0.05).The CTFC immediately after operation in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The level of LVEF after operation was higher than before operation,and the level of LVESD and LVEDD were lower than before operation,the difference was statistically significant(P<0.05

关 键 词：替罗非班 腺苷 冠心病 经皮冠状动脉介入治疗 微循环 心脏功能试验 

分 类 号：R541.4[医药卫生—心血管疾病]