反复上呼吸道感染患儿微量元素、Th1/Th2变化及其意义  

Changes of Trace Elements and Th1/Th2 in Children with Recurrent Upper Respiratory Tract Infection and their Significance

作　　者：訾敏 马红霞 ZI Min;MA Hongxia(Department of General Pediatrics,Shenmu Hospital,Yulin Shaanxi 719300)

机构地区：[1]神木市医院普儿科,陕西榆林719300

出　　处：《医学临床研究》2025年第1期85-87,91,共4页Journal of Clinical Research

摘　　要：【目的】探讨反复上呼吸道感染(RRTI)患儿微量元素及辅助性T细胞1(Th1)/辅助性T细胞2(Th2)变化及其意义。【方法】选取2019年10月至2021年10月本院收治的62例RRTI患儿(观察组),并选取同期在本院体检的60例健康儿童(对照组),比较两组一般资料、微量元素[铁(Fe)、铅(Pb)、镁(Mg)、锌(Zn)、钙(Ca)]及Th1/Th2,采用Pearson分析微量元素与Th1/Th2的相关性,采用Logistic回归分析RRTI发生的影响因素。【结果】两组性别、年龄、体重指数(BMI)及早产、剖宫产、营养不良、户外活动占比比较,差异无统计学意义(P>0.05);观察组家庭成员吸烟、抗菌药物使用次数≥3次/年占比高于对照组,母乳喂养占比低于对照组(P<0.05);两组Pb、Mg水平比较,差异无统计学意义(P>0.05);观察组Fe、Zn、Ca、Th1/Th2低于对照组(P<0.05)。Pearson相关性分析显示:微量元素Fe、Zn、Ca与Th1/Th2均呈正相关(P<0.05);Logistic回归分析显示:家庭成员吸烟、抗菌药物使用次数≥3次/年及Fe、Zn、Ca、Th1/Th2低均为RRTI发生的危险因素,母乳喂养是RRTI发生的保护因素(P<0.05)。【结论】RRTI患儿微量元素缺乏与Th1/Th2免疫平衡密切相关,且是RRTI发生的重要影响因素。【Objective】To investigate the changes and significance of trace elements and helper T cell 1(Th1)/Helper T cell 2(Th2)in children with recurrent upper respiratory tract infection(RRTI).【Methods】Sixty-two children with RRTI admitted to our hospital from October 2019 to October 2021(the observation group)were selected,and 60 healthy children(the control group)who underwent physical examination in our hospital during the same period were selected.General information,trace elements[iron(Fe),lead(Pb),magnesium(Mg),zinc(Zn),calcium(Ca)]and Th1/Th2 levels of the two groups were compared.The correlation between trace elements and Th1/Th2 was analyzed by Pearson,and the influencing factors of RRTI were analyzed by Logistic regression.【Results】There were no significant differences in gender,age,body mass index(BMI),preterm birth,cesarean section,malnutrition and outdoor activities between the two groups(P>0.05).The proportion of family member's smoking and using antibacterial drugs≥3 times/year in the observation group was higher than that in the control group,and the proportion of breastfeeding was lower than that in the control group(P<0.05).There was no significant difference in Pb and Mg levels between the two groups(P>0.05).Fe,Zn,Ca and Th1/Th2 in the observation group were lower than those in the control group(P<0.05).Pearson correlation analysis showed that Fe,Zn,Ca were positively correlated with Th1/Th2(P<0.05).Logistic regression analysis showed that family members smoking,antimicrobial use times≥3 times/year and low Fe,Zn,Ca,Th1/Th2 were all risk factors for RRTI development,and breastfeeding was a protective factor for RRTI development(P<0.05).【Conclusion】Trace element deficiency in children with RRTI is closely related to Th1/Th2 immune balance,and is an important factor affecting the development of RRTI.

关 键 词：呼吸道感染 痕量元素 TH1细胞 TH2细胞 

分 类 号：R725.176[医药卫生—儿科]