RMPP和MPP患儿的肺功能、炎症因子及临床转归分析  

Lung Function,Inflammatory Factors and Clinical Outcomes of RMPP and MPP Children

作　　者：徐梅芳 王仁珍[1] XU Meifang;WANG Renzhen(Department of Pediatrics,Xiangcheng People's Hospital of Suzhou,Suzhou Jiangsu 215000)

机构地区：[1]苏州市相城人民医院儿科,江苏苏州215000

出　　处：《医学临床研究》2025年第1期92-94,98,共4页Journal of Clinical Research

摘　　要：【目的】探讨难治性肺炎支原体肺炎(RMPP)和肺炎支原体肺炎(MPP)患儿的肺功能、炎症因子及临床转归。【方法】选取2019年1月至2022年1月在本院诊治的110例MPP患儿,其中48例RMPP患儿纳入RMPP组,62例普通MPP患儿纳入MPP组。比较两组急性期和恢复期肺功能指标[第一秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC]、血清炎症因子[白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(INF-γ)]水平、肺功能异常发生情况。【结果】两组恢复期FEV_(1)、FVC均高于急性期(P<0.05),但两组急性期和恢复期的FEV_(1)/FVC比较,差异无统计学意义(P>0.05);RMPP组急性期和恢复期的FEV_(1)、FVC均低于MPP组(P<0.05)。两组恢复期血清IL-2、IL-6、TNF-α、INF-γ水平均低于急性期(P<0.05);RMPP组恢复期血清IL-2、IL-6、TNF-α、INF-γ水平高于MPP组(P<0.05)。两组急性期肺功能异常发生率比较,差异无统计学意义(P>0.05);RMPP组恢复期肺功能正常的患儿比例低于MPP组,限制性通气功能障碍的患儿比例高于MPP组(P<0.05)。【结论】与MPP患儿相比,RMPP患儿的肺功能损伤程度、炎症反应更加严重,从急性期到恢复期,RMPP和MPP患儿的肺功能均改善,炎症反应均减轻,但RMPP患儿恢复和临床转归较差,恢复期限制性通气功能障碍的比例更高。【Objective】To investigate the pulmonary function,inflammatory factors and clinical outcomes of children with refractory mycoplasma pneumoniae pneumonia(RMPP)and Mycoplasma pneumoniae pneumonia(MPP).【Methods】A total of 110 children with MPP treated in our hospital from January 2019 to January 2022 were selected,of which 48 children with RMPP were included in the RMPP group and 62 children with common MPP were included in the MPP group.Levels of the pulmonary function indexes in acute stage and convalescent stage in terms of[first second forced expiratory volume(FEV_(1)),forced vital capacity(FVC),FEV_(1)/FVC],serum inflammatory factors[interleukin-2(IL-2),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interferon-γ(INF-γ)]and abnormal lung function were compared between the two groups.【Results】FEV_(1)and FVC in the recovery stage were higher than those in the acute stage(P<0.05),but there was no significant difference in FEV_(1)/FVC in the acute stage and the recovery stage between the two groups(P>0.05).The FEV_(1)and FVC of the RMPP group in acute stage and recovery stage were lower than those of the MPP group(P<0.05).Serum levels of IL-2,IL-6,TNF-αand INF-γin the recovery stage were lower than those in the acute stage(P<0.05).The serum levels of IL-2,IL-6,TNF-αand INF-γin RMPP group were higher than those in the MPP group(P<0.05).There was no significant difference in the incidence of abnormal lung function between the two groups(P>0.05).The proportion of children with normal lung function in the RMPP group was lower than that in the MPP group,and the proportion of children with restrictive ventilation dysfunction was higher than that in the MPP group(P<0.05).【Conclusion】Compared with children with MPP,children with RMPP have more severe lung function injury and inflammation.From the acute stage to the convalescent stage,both children with RMPP and MPP have improved lung function and reduced inflammation.However,children with RMPP have poor recovery and clinical outcomes,and a higher

关 键 词：肺炎 支原体 呼吸功能试验 炎症趋化因子类 预后 

分 类 号：R725.63[医药卫生—儿科]