热分析技术在药品检验与研发中的应用  

Application of Thermal Analysis Techniques in Pharmaceutical Testing and Research

作　　者：张金秋 严菲 黄朝瑜 戚繁 邵方娴 芦丽 杨香 Zhang Jinqiu;Yan Fei;Huang Chaoyu;Qi Fan;Shao Fangxian;Lu Li;Yang Xiang(Jiangsu Institute for Food and Drug Control,Nanjing 210019,China)

机构地区：[1]江苏省食品药品监督检验研究院,江苏南京210019

出　　处：《广东化工》2025年第2期93-94,150,共3页Guangdong Chemical Industry

基　　金：江苏省药品监督管理局药品监管科研计划项目(202209)。

摘　　要：热分析技术在药品检验与研究中具有重要作用。通过差示扫描量热法(DSC)、热重分析法(TGA)、动态机械分析法(DMA)和热机械分析法(TMA)等技术,研究人员可以获得药物的热稳定性、纯度、晶型和相容性等关键信息。这些信息对于药品的研发和质量控制至关重要,有助于确保药品的安全性和有效性。本文综述了热分析技术的基本原理与方法,探讨了其在药品检验和研发中的具体应用,并分析了其优点与局限性,展望了未来的发展方向。Thermal analysis techniques play a crucial role in pharmaceutical testing and research.Techniques such as Differential Scanning Calorimetry(DSC),Thermogravimetric Analysis(TGA),Dynamic Mechanical Analysis(DMA),and Thermomechanical Analysis(TMA)provide researchers with key information on drug thermal stability,purity,crystal form,and compatibility.This information is vital for drug development and quality control,ensuring drug safety and efficacy.This paper reviews the basic principles and methods of thermal analysis techniques,discusses their specific applications in pharmaceutical testing and development,and analyzes their advantages and limitations.The future development directions of these techniques are also explored.

关 键 词：热分析技术 药品检验 药品研发 

分 类 号：TQ[化学工程]