钙敏感受体在老年皮肤病理生理中的作用研究进展  

Role of calcium-sensing receptors in the pathophysiology of skin of the elderly

作　　者：艾芳婷 孙紫君 苗国英[1] 姚春霞 Ai Fangting;Sun Zijun;Miao Guoying;Yao Chunxia(Department of Dermatology,Affiliated Hospital of Hebei University of Engineering University,Hebei Provincial Key Laboratory of Dermatology Clinical Immunology,Handan 056000,Hebei,China)

机构地区：[1]河北工程大学附属医院皮肤科,河北省皮肤临床免疫重点实验室,邯郸056000

出　　处：《中华皮肤科杂志》2025年第1期76-79,共4页Chinese Journal of Dermatology

基　　金：河北省重点研发计划项目(20377795D);河北省高等学校科学技术研究项目(ZD2022002)。

摘　　要：钙敏感受体(CaSR)作为一种广泛表达于人体多种细胞类型中的G蛋白偶联受体,近年来在老年皮肤病理生理中的作用逐渐被揭示。本文综述了近年来CaSR在老年人皮肤中的功能和调控机制,以及其在维持皮肤屏障、调节炎症反应和影响老化过程中的作用,为老年人皮肤病防治提供新的思路。Calcium-sensing receptors(CaSRs)are a kind of G protein-coupled receptors widely expressed in various cell types in the human body,and their roles in the pathophysiological changes in skin of the elderly have been gradually revealed in recent years.This review summarizes the functions and regulatory mechanisms of CaSRs in skin of the elderly in recent years,and emphasizes their roles in maintaining the skin barrier,regulating inflammatory responses,and influencing the aging process,aiming to provide new insights into the prevention and treatment of skin disorders in the elderly.

关 键 词：皮肤疾病 老年人 受体 钙敏感 炎症 皮肤衰老 皮肤屏障 

分 类 号：R73[医药卫生—肿瘤]