Biomolecular condensates modulate membrane remodeling  

作　　者：Emma K.Meese Lucia C.Strader 

机构地区：[1]Department of Biology,Duke University,Durham,NC,USA

出　　处：《Molecular Plant》2025年第1期17-18,共2页分子植物(英文版)

基　　金：supported by the National Science Foundation(PGRP BIO-2112056);the National Institutes of Health(R35 GM136338);Duke Beyond the Horizons funds.

摘　　要：Cellular function relies on numerous diverse processes,all happening simultaneously.One means by which cells manage these processes is through the use of biomolecular condensates.These membrane-less compartments,often created through phase separation,influence cellular mechanisms ranging from reaction kinetics to biomolecule sequestration(Banani et al.,2017).In plants,biomolecular condensates play roles in desiccation tolerance(Belott et al.,2020),transcriptional control(Powers et al.,2019;Bondos et al.,2021),and a myriad of other diverse processes(Emenecker et al.,2021).Recently,condensates have been discovered to have the ability to exert forces through interactions with cellular components.For example,capillary interaction between condensates and other cellular components can generate force;however,more study is necessary to elucidate these mechanisms and interactions(Kusumaatmaja et al.,2021;Gouveia et al.,2022).A recent work by Wang et al.(2024)has revealed new insights into how biomolecular condensates may exert forces on membranes through bending and scission.Further,they provide in silico methods and a model to investigate the forces at play during membrane wetting.

关 键 词：FORCES KINETICS BENDING 

分 类 号：O65[理学—分析化学]