柚皮苷对破骨细胞作用的机制研究进展  

Research Progress on the Mechanism of Naringin on Osteoclasts

作　　者：何紫移 金环 马陈[2] 沈霖[2] 帅波 HE Ziyi;JIN Huan;MA Chen;SHEN Lin;SHUAI Bo(School of Sports Medicine,Wuhan Sports University,Wuhan 430079 Hubei,China;Department of Integrated Traditional Chinese and Western Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430079 Hubei,China)

机构地区：[1]武汉体育学院运动医学院,湖北武汉430079 [2]华中科技大学同济医学院附属协和医院中西医结合科,湖北武汉430079

出　　处：《中药新药与临床药理》2025年第2期294-298,共5页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金项目(82174182,81974546,82004201);中央高校基本科研业务费专项资金资助(2019kfyRCPY093)。

摘　　要：骨质疏松症(OP)是一种常见的代谢类骨关节疾病,在我国中老年人群中发病率高,且难以被治愈,严重降低了患者的生活质量。含骨碎补的补肾强骨方是抗骨质疏松症的有效方剂,其中骨碎补的活性成分—柚皮苷已被证实可作用于破骨细胞抑制骨吸收。为探讨柚皮苷对破骨细胞的作用机制,该文综述了近20年来的相关研究,发现柚皮苷可以通过调控相关信号通路,调节免疫细胞以及模拟雌激素样作用调控破骨细胞,为临床运用柚皮苷治疗骨质疏松症提供了理论基础,也为开创原研药物治疗骨质疏松症提供了思路。Osteoporosis(OP)is a common metabolic bone and joint disease with a high incidence among middle-aged and elderly people in China.It is difficult to cure and significantly reduces patients'quality of life.The kidney-tonifying and bone-strengthening prescription containing Drynariae Rhizoma is an effective formula for anti-OP.Naringin,the active ingredient of Drynariae Rhizoma,has been proven to act on osteoclasts to inhibit bone resorption.To explore the mechanism of naringin on osteoclasts,this article reviews relevant research conducted over the past two decades.It has been found that naringin can regulate osteoclasts by modulating related signaling pathways,regulating immune cells,and mimicking estrogen-like effects.Our study may provide a theoretical basis for the clinical use of naringin in the treatment of OP and offer ideas for the development of original brand-named drugs for OP treatment.

关 键 词：骨碎补 柚皮苷 破骨细胞 骨质疏松症 骨吸收 信号通路 

分 类 号：R285.5[医药卫生—中药学]