microRNA调控血吸虫生长发育的研究进展  

Advances in research on schistosome growth and development regulated by microRNA

作　　者：孙成松 王毓洁 SUN Cheng-song;WANG Yu-jie(Anhui Provincial Center for Disease Control and Prevention,Hefei 230601,China)

机构地区：[1]安徽省疾病预防控制中心,合肥230601

出　　处：《中国人兽共患病学报》2025年第1期94-101,共8页Chinese Journal of Zoonoses

基　　金：安徽省卫生健康科研项目(No.AHWJ2022a009);安徽省自然科学基金(No.2008085QH430);安徽省第十四批“115”产业创新团队项目联合资助。

摘　　要：microRNA(miRNA)是一类大小约22 nt的内源性非编码RNA,其通过与靶基因mRNA序列3′端非翻译区(3′untranslated region,3′UTR)互补结合,促使mRNA降解或抑制翻译,进而调节众多的生理和病理过程。越来越多的证据表明,miRNA在血吸虫生长发育以及与宿主间相互作用过程中发挥重要的调控作用。本文着重阐述不同来源miRNA调控血吸虫生长发育的研究进展,为血吸虫生物学与血吸虫病防治研究提供新的思路。MicroRNAs(miRNAs)are a class of endogenous non-coding RNAs of approximately 22 nt,which lead to the degradation of target messenger RNA(mRNA)or inhibition of mRNA translation through complementary binding to the 3′untranslated region(3′UTR)in mRNA sequences,thereby regulating numerous physiological and pathological processes.Evidence increasingly suggests that miRNAs play important regulatory roles in the growth and development of schistosomes,and their interactions with hosts.This review highlights research advances in the regulation of schistosome growth and development by miRNAs from different sources,thus providing new ideas regarding schistosome biology and schistosomiasis control.

关 键 词：血吸虫 MICRORNA 生长发育 

分 类 号：R383.2[医药卫生—医学寄生虫学]