非免疫缺陷者感染短链少食诺卡菌复合群的1例报告  

Non-immunodeficient patient infected with Nocardia brevicatena/paucivorans complex:a case report

作　　者：全斌 韩文正 杨江华 王文节 段纯 QUAN Bin;HAN Wen-zheng;YANG Jiang-hua;WANG Wen-jie;DUAN Chun(Department of Infectious Diseases,The First Affiliated Hospital of Wannan Medical College,Wuhu 241001,China;Department of Clinical Laboratory,The First Affiliated Hospital of Wannan Medical College,Wuhu 241001,China)

机构地区：[1]皖南医学院第一附属医院感染性疾病科,芜湖241001 [2]皖南医学院第一附属医院检验科,芜湖241001

出　　处：《中国人兽共患病学报》2025年第1期102-106,共5页Chinese Journal of Zoonoses

基　　金：安徽省卫生健康科研项目基金(No.AHWJ2023A20546);皖南医学院中青年科研项目(No.WK2021F20)联合资助。

摘　　要：目的报告1例非免疫缺陷者感染短链少食诺卡菌复合群病例,为诺卡菌的临床诊治和防控提供参考依据。方法回顾性分析患者的临床资料、检查特点及治疗措施,并结合相关文献分析。结果患者男性,54岁,无慢性病,因反复腰痛伴发热不适而多次住院,MRI显示腰椎旁软组织及腹腔多发脓肿,免疫功能检查均正常,传统病原学培养为阴性,宏基因组二代测序(mNGS)鉴定为短链少食诺卡菌复合群感染,予以复方磺胺甲噁唑片等抗感染方案安全有效,随访1年余未见复发。结论诺卡菌是一种条件致病菌,但非免疫缺陷的人群仍有感染风险,且多表现为皮肤和软组织部位病变,临床医师需提高警惕,减少漏诊或误诊。Nocardia is an emerging worldwide distributed zoonotic pathogen,and the common infected population is immunocompromised.This article reports a case of non-immunodeficient infected with Nocardia brevicatena/paucivorans complex,combined with literature analysis,aiming to improve scientific reference for clinical diagnosis,treatment and prevention of Nocardia.The patient was a 54-year-old male with no chronic diseases,hospitalized due to repeated low back pain and fever discomfort,MRI showed lumbar soft tissue and abdominal abscess.The examination of the immune function aspect was normal,conventional pathogen culture was negative.mNGS showed Nocardia brevicatena/paucivorans complex infection.The anti-infection regimen of SMZ was safe and effective,and no recurrence was observed after 1 year of follow-up.Although Nocardia is an opportunistic pathogen,immunocompetent people are still at risk of infection and often present with skin and soft tissue lesions.

关 键 词：短链少食诺卡菌复合群 短链诺卡菌 少食诺卡菌 脓肿 

分 类 号：R378.9[医药卫生—病原生物学]