mRNA三级结构局部碱基对螺旋参量对蛋白质折叠速率的影响  

Effect of Local Base-pair Helical Parameters of mRNA Tertiary Structure on Protein Folding Rate

作　　者：彭诗雅 李瑞芳[1] 宋鑫伟 高姗 田旭 邓俊超 PENG Shiya;LI Ruifang;SONG Xinwei;GAO Shan;TIAN Xu;DENG Junchao(College of Physics and Electronic Information,Inner Mongolia Normal University,Hohhot 010022,China)

机构地区：[1]内蒙古师范大学物理与电子信息学院,内蒙古呼和浩特010022

出　　处：《内蒙古师范大学学报(自然科学版)》2025年第1期81-91,共11页Journal of Inner Mongolia Normal University(Natural Science Edition)

基　　金：内蒙古自治区自然科学基金资助项目“mRNA对蛋白质折叠速率影响机制的研究”(2023MS03042)。

摘　　要：为研究局部碱基对螺旋参量对蛋白质折叠速率的作用机制,收集了100个具有实验折叠速率的蛋白质,通过计算获得各个蛋白质相对应的mRNA三级结构数据,筛选出其中的局部碱基对螺旋参量,深入研究这些参量与蛋白质折叠速率之间的相关性;将所选蛋白质按照折叠类型和二级结构进行分组,进而分析这些参量对不同类蛋白质折叠速率影响的差异。研究结果表明,蛋白质折叠速率与X-disp、Y-disp、h-Rise、Incl(η)、Tip(θ)和h-Twist六个参量存在不同程度的相关性,说明mRNA三级结构的局部碱基对螺旋参量在调控蛋白质折叠速率方面发挥了重要作用。To explore the mechanism underlying the effect of local base-pair helical parameters on the protein folding rate,this study collected 100 proteins with experimental folding rates for research.The mRNA tertiary structure data of each protein were obtained computationally,and the local base-pair helical parameters were filtered out.The correlation between these parameters and the protein folding rate was studied in depth.The selected proteins were grouped according to the folding type and secondary structure.Further,the study analyzed the differences in the effects of these parameters on the folding rates of different classes of proteins.The results show that the protein folding rate is correlated with six parameters of X-disp,Y-disp,h-Rise,Inc(lη),Tip,and h-Twist to varying degrees,which indicates that the local basepair helical parameters of mRNA tertiary structure play an important role in regulating the protein folding rate.

关 键 词：RNA三级结构 局部碱基对螺旋参量 蛋白质折叠速率 相关性 

分 类 号：Q61[生物学—生物物理学]