自身免疫性疾病中NETs与免疫细胞的相互作用  

The Interaction Between NETs and Immune Cells in Autoimmune Diseases

作　　者：高然 刘晨雨 邓超华 胡维琨[1,2] Gao Ran;Liu Chenyu;Deng Chaohua(Department of Ophthalmology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Ophthalmology,Tianyou Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430064,China)

机构地区：[1]华中科技大学同济医学院附属同济医院眼科,武汉430030 [2]武汉科技大学附属天佑医院眼科,武汉430064

出　　处：《华中科技大学学报(医学版)》2025年第1期129-136,共8页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：湖北省卫生健康委员会科研资助项目(No.WJ2021M211)。

摘　　要：近年来,随着技术水平的提升,人们对中性粒细胞外捕网(neutrophil extracellular traps,NETs)有了更加深入的了解,大量的研究表明NETs与自身免疫有密切关系,可通过多种机制参与自身免疫性疾病的发生发展,如作为自身抗原的来源、激活补体系统或作用于其他免疫细胞等,其中,NETs与免疫细胞相互作用对疾病发生发展具有重要意义,本文主要概述了自身免疫性疾病中NETs与树突状细胞、巨噬细胞、B细胞、CD4^(+)T细胞的联系,以及通过影响NETs水平和干预NETs与免疫细胞的相互作用,为治疗自身免疫性疾病提供新的策略。In recent years,our understanding of neutrophil extracellular traps(NETs)has been deepened with advancements in technology.Extensive research has demonstrated that NETs are intricately linked to autoimmunity and contribute to the pathogenesis of autoimmune diseases through multiple mechanisms,such as serving as a source of self-antigens,activating the complement system,or modulating other immune cells.Notably,the interaction between NETs and immune cells plays a critical role in disease progression.This article primarily reviews the relationship of NETs with dendritic cells,macrophages,B cells,and CD4~+T cells in autoimmune diseases,providing insights into potential therapeutic strategies by NETs level modulation and NETs-immune cell interactions intervenion.

关 键 词：中性粒细胞外捕网 树突状细胞 巨噬细胞 B细胞 CD4^(+)T细胞 自身免疫性疾病 

分 类 号：R593.2[医药卫生—内科学]