神经嵴细胞在颅骨缺损修复中的研究进展  

Research progress of neural crest cells in repairing skull defect

作　　者：陈奇 谷体英 王羽 邵国 张春阳[1] 张磊[1] 杜秉承 赵志军[1] CHEN Qi;GU Tiying;WANG Yu;SHAO Guo;ZHANG Chunyang;ZHANG Lei;DU Bingcheng;ZHAO Zhijun(Department of Neurosurgery,The First Affiliated Hospital of Baotou Medical College,Baotou 014010,China;不详)

机构地区：[1]包头医学院第一附属医院/包头医学院,包头014010 [2]济南市莱芜区高庄街道社区卫生服务中心 [3]深圳市龙岗区第三人民医院

出　　处：《临床神经外科杂志》2025年第1期106-108,113,共4页Journal of Clinical Neurosurgery

基　　金：国家自然科学基金预算制项目(82360188)。

摘　　要：神经嵴细胞(NCCs)是脊椎动物早期发育过程中从神经管背缘发育而来的一组独特的细胞,具有很强的增殖能力。颅骨缺损修复组织工程是神经外科重要方向,随着NCCs的研究,为利用NCCs进行颅骨缺损修复带来了新思路。本文概述了NCCs在颅骨缺损修复中的效果及相关成骨机制,同时探讨其用于颅骨缺损修复的应用前景,旨在为NCCs在颅骨缺损修复的研究及应用提供一定的理论依据。Neural crest cells(NCCs)are a unique group of cells that develop from the dorsal margin of the neural tube during the early development of vertebrates and possess a strong proliferative ability.Tissue engineering for cranial defect repair is an important direction in neurosurgery.With the research on NCCs,new ideas have been brought about for the use of NCCs in cranial defect repair.This article outlines the effects of NCCs in cranial defect repair and the related osteogenic mechanisms.Meanwhile,it explores the application prospects of their use in cranial defect repair,aiming to provide certain theoretical bases for the research and application of NCCs in cranial defect repair.

关 键 词：神经嵴细胞 颅骨 缺损修复 成骨分化 

分 类 号：R651[医药卫生—外科学]