蜕膜自然杀伤细胞在子痫前期发病机制中的研究进展  

Decidual Natural Killer Cells in the Pathogenesis of Preeclampsia:A Review

作　　者：王晶[1] 王永红(审校)[1] WANG Jing;WANG Yong-hong(Department of Obstetrics and Gynecology,Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二医院妇产科,太原030001

出　　处：《国际妇产科学杂志》2025年第1期88-93,共6页Journal of International Obstetrics and Gynecology

基　　金：山西省自然科学基金面上项目(202403021211166)。

摘　　要：子痫前期(preeclampsia,PE)是妊娠期特有的疾病,是孕产妇和围产儿发病和死亡的主要原因。目前PE的病因和发病机制尚未完全阐明,滋养细胞侵袭不足和子宫螺旋动脉重塑障碍是导致PE发病的重要因素。有研究表明,蜕膜自然杀伤(decidual natural killer,dNK)细胞具有参与子宫螺旋动脉重塑、调控滋养细胞入侵、参与母胎界面免疫耐受、促进胎儿生长等作用。dNK细胞数量、功能和表型等的变化,dNK细胞与绒毛外滋养细胞上配体结合的相应受体表达异常,dNK细胞分泌的细胞因子的变化,可能是PE发病的原因。综述dNK细胞在PE发生发展中的作用,为PE的诊断和治疗提供可靠的理论依据。Preeclampsia(PE)is a pregnancy-specific disorder that is a leading cause of maternal and perinatal morbidity and mortality.At present,the etiology and pathogenesis of PE remain incompletely understood,although insufficient trophoblast invasion and impaired uterine spiral artery remodeling are considered major contributing factors.Studies suggest that decidual natural killer(dNK)cells play crucial roles in uterine spiral artery remodeling,regulating trophoblast invasion,mediating maternal-fetal interface immune tolerance,and promoting fetal growth.Alterations in dNK cell number,function,and phenotype,aberrant expression of receptors for ligands on extravillous trophoblasts,and changes in the cytokine profile secreted by dNK cells may contribute to the development of PE.This review summarizes the role of dNK cells in the pathogenesis of PE,providing a theoretical basis for improved diagnosis and treatment.

关 键 词：先兆子痫 蜕膜 杀伤细胞 天然 子宫螺旋动脉 血管重塑 滋养层 

分 类 号：R714.244[医药卫生—妇产科学]