长链非编码RNA在继发性脊髓损伤中的作用及中医药干预的研究进展  

The Function of Long Non-coding RNA in Spinal Cord Injury and Research Progress in TCM Intervention

作　　者：许多芳 张彦军[2] 郭铁峰[2] 李家明 江朔轩 刘晏东 XU Duofang;ZHANG Yanjun;GUO Tiefeng;LI Jiaming;JIANG Shuoxuan;LIU Yandong(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院,甘肃兰州730050

出　　处：《西部中医药》2025年第1期99-105,共7页Western Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(82060879)。

摘　　要：从长链非编码RNA(long noncoding RNA,lncRNA)与脊髓损伤发生发展的相关性、lncRNA与脊髓损伤治疗的相关性及中医药对脊髓损伤-lncRNA的干预等方面阐述了lncRNA与脊髓损伤相关性及中药干预机制的研究进展,指出lncRNA在脊髓损伤中存在差异性表达并在脊髓损伤的发展及治疗过程中有着重要的作用,可以通过调控lncRNA在脊髓损伤过程中的表达,为脊髓损伤找到潜在的治疗靶点,以期为脊髓损伤的防治提供新的参考方向。Research progress of the correlation between long noncoding RNA(lncRNA)and spinal cord injury,intervention mechanism with TCM was illustrated from the connections of lncRNA with the incidence and development of spinal cord injury,the relationship between both of them and TCM intervention of spinal cord injury-IncRNA,relevant studies have shown that lncRNA expressed differentially in spinal cord injury,and it played a vital role in the development of spinal cord injury and therapeutic course,therefore,it is possible to find the potential therapeutic targets for spinal cord by regulating the expressions of lncRNA in the course of spinal cord injury,which could provide new direction for the prevention and the treatment of the disease.

关 键 词：脊髓损伤 长链非编码RNA 中医药 研究进展 

分 类 号：R274.9[医药卫生—中西医结合]