基于细胞铁死亡探讨中医药靶向治疗胃癌的分子机制及其研究进展  

Molecular Mechanism of TCM Targeted Therapy for Gastric Cancer Based on Ferroptosis and Its Research Progress

作　　者：赵多明[1] 李建花 王晓怀[1] 黄邦荣[1] 张志明 ZHAO Duoming;LI Jianhua;WANG Xiaohuai;HUANG Bangrong;ZHANG Zhiming(Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃省中医院,甘肃兰州730050

出　　处：《西部中医药》2025年第1期123-127,共5页Western Journal of Traditional Chinese Medicine

基　　金：甘肃省中医药科研项目(GZKP-2021-37);甘肃省肿瘤多学科防治诊疗中心建设项目(甘卫中医函[2023]63号)。

摘　　要：从胃癌与铁死亡、三种经典信号通路诱导铁死亡、中医对胃癌铁死亡的认识、中医药在胃癌铁死亡的应用等方面综述了铁死亡的发生机制及其在胃癌细胞生长繁殖中的作用,并揭示了中医药诱导胃癌细胞铁死亡的发生发展机制,以期为临床治疗胃癌提供新思路、新方案。The mechanism of ferroptosis and its function in stomach cancer cell growth and reproduction was reviewed from gastric cancer and ferroptosis,ferroptosis induced by three classical signaling pathways,the understanding to ferroptosis of gastric cancer in TCM,the application of TCM in ferroptosis of gastric cancer,meanwhile the mechanism of ferroptosis of gastric cancer induced by TCM was revealed,with a view to providing new thinking and program for clinical therapy.

关 键 词：胃癌 铁死亡 中医药 靶向治疗 研究进展 

分 类 号：R273[医药卫生—中西医结合]