亚麻籽膳食粉联合强化膳食纤维益生菌对腹膜透析患者功能性便秘的影响  

Effects of Flaxseed Meal Joined with Probiotics with Fortified Dietary Fiber on Functional Constipation in Peritoneal Dialysis Patients

作　　者：李涛[1] 谢赛 刘一卓[1] 冯爱桥[1] LI Tao;XIE Sai;LIU Yizhuo;FENG Aiqiao(Xiaogan Hospital,Wuhan University of Science and Technology,Xiaogan 432100,China)

机构地区：[1]武汉科技大学附属孝感医院,湖北孝感432100

出　　处：《西部中医药》2025年第1期128-132,共5页Western Journal of Traditional Chinese Medicine

基　　金：孝感市自然科学基金(XGKJ2021010085)。

摘　　要：目的:分析亚麻籽膳食粉联合强化膳食纤维益生菌预防及治疗腹膜透析患者功能性便秘的真实世界研究。方法:将90例腹膜透析后功能性便秘患者按随机数表法分为观察组和对照组,每组45例。两组患者均进行常规西医治疗,在此基础上,对照组采用亚麻籽膳食粉进行治疗;观察组采用亚麻籽膳食粉联合强化膳食纤维益生菌进行治疗。比较两组临床疗效、营养状况及胃肠道功能情况。结果:治疗后,总有效率观察组为82.22%(37/45),对照组为60.00%(27/45),两组比较差异有统计学意义(P<0.05)。治疗前后两组患者总蛋白、血红蛋白水平无明显变化(P>0.05);治疗后,两组患者前白蛋白水平较治疗前升高,且观察组高于对照组,两组患者白蛋白水平较治疗前降低,且观察组低于对照组(P<0.05)。治疗前后两组患者肱三头肌皮肤褶皱厚度、上臂中点周径值无明显变化(P>0.05);治疗后,两组患者IgG、IgA、IgM、补体C3、淋巴细胞计数水平较治疗前升高(P<0.05),且观察组升高更明显(P<0.05)。治疗前后两组患者高密度脂蛋白胆固醇水平无明显变化(P>0.05);治疗后两组患者低密度脂蛋白胆固醇、甘油三酯、总胆固醇均较治疗前降低,且观察组低于对照组(P<0.05)。观察组患者腹泻发生率为26.67%(12/45)、便秘发生率为20.00%(10/45),对照组分别为48.89%(22/45)和44.44%(20/45),两组比较差异有统计学意义(P<0.05);两组患者呕吐、反流、腹胀、腹痛发生情况比较,差异无统计学意义(P>0.05)。结论:亚麻籽膳食粉联合强化膳食纤维益生菌不仅能有效改善腹膜透析患者功能性便秘情况,还能改善患者营养状况,提高患者机体免疫力,恢复胃肠道功能,预防功能性便秘的发生。Objective:To analyze real-world study of flaxseed meal and probiotics with fortified dietary fiber in the prevention and treatment of functional constipation(FC)in peritoneal dialysis patients.Methods:A total of 90 FC patients after peritoneal dialysis were divided into the observation group and the control group according to random number table method with 45 cases in each group.Both groups accepted conventional therapy of Western medicine,the control group was treated with flaxseed meal,and the observation group took flaxseed meal and probiotics with fortified dietary fiber orally.To compare clinical effects,nutritional conditions and gastrointestinal functions between both groups.Results:After the treatment,total effective rate of the observation group was 82.22%(37/45),higher than 60.00%(27/45)of the control group,and the difference had statistical meaning(P<0.05).No significant difference has been found in the levels of total protein and hemoglobin before and after the treatment(P>0.05);after the treatment,the levels of hemoglobin were higher than before the treatment in two groups,and the observation group was higher than the control group,the levels of hemoglobin were lowered than before the treatment,and the observation group was lower than the control group(P<0.05).There was no difference in skin fold thickness of the triceps brachii and midpoint perimeter diameter value of the upper arm before and after the treatment(P>0.05);after the treatment,the levels of IgG,IgA and IgM,complement C3 and lymphocyte count in the two groups were elevated than before the treatment(P<0.05),and the increase of the observation group was more apparent(P<0.05).No obvious change existed in the levels of high-density lipoprotein cholesterol(HDL-C)before and after the treatment(P>0.05);after the treatment,the levels of LDL-C,triglyceride,total cholesterol(TC)were lower compared with before the treatment,and the observation group was lower than the control group(P<0.05).The incidences of diarrhea and constipation of the observa

关 键 词：功能性便秘 亚麻籽膳食粉 强化膳食纤维益生菌 腹膜透析 

分 类 号：R256.35[医药卫生—中医内科学]